Distinctive and critical roles for cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in mice
Distinctive and critical roles for cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in mice
复制标题
DOI：
10.1016/j.micinf.2011.04.003
复制
发表时间：
2011-08-01
影响因子：
5.8
通讯作者：
Agui, Takashi
中科院分区：
文献类型：
--
作者：
Simon, Ayo Yila;Sasaki, Nobuya;Agui, Takashi
呼吸道病毒感染会导致严重的肺损伤，而宿主免疫反应可能是其中的一个重要原因。目前，尚不完全清楚肺损伤在多大程度上是宿主防御的必然结果。在本报告中，我们使用功能基因组学方法来表征细胞免疫和免疫炎症反应在耐药 C57BL/6J 和易感 DBA/2J 小鼠仙台病毒感染免疫病理学中的关键作用。受感染的小鼠表现出免疫炎症反应，其特征是中性粒细胞和单核细胞涌入肺部。 DBA/2J 小鼠产生了强烈的免疫反应，在感染过程中连续两波细胞因子/趋化因子基因显着上调。而 C57BL/6J 小鼠表现出有效的免疫反应，且病理不太严重，并且该品系的免疫炎症反应基因簇在第 4 天完全上调。总体而言，DBA/2J 小鼠表现出失调的超炎症细胞因子/趋化因子级联，不能限制病毒传播，从而导致严重肺部病变的倾向。这种反应类似于严重的人类呼吸道副粘病毒感染，这将作为阐明导致呼吸道病毒感染中严重免疫病理学的超免疫炎症反应的模型。 (C) 2011 年巴斯德研究所。由 Elsevier Masson SAS 出版。版权所有。
Respiratory viral infections result in severe pulmonary injury, to which host immune response may be a significant contributor. At present, it is not entirely clear the extent to which lung injury is a necessary consequence of host defense. In this report, we use functional genomics approach to characterize the key roles of cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in resistant C57BL/6J and susceptible DBA/2J mice. Infected mice manifested an immune-inflammatory response characterized by the pulmonary influx of neutrophils and mononuclear cells. DBA/2J mice mounted a vigorous immune response, with significant up-regulation of cytokine/chemokine genes in two successive waves through the course of infection. Whereas, C57BL/6J mice displayed an efficient immune response with less severe pathology and clusters of immune-inflammatory responsive genes were exclusively up-regulated on day 4 in this strain. Overall, DBA/2J mice exhibited a dysregulated hyper-inflammatory cytokine/chemokine cascades that does not limit viral spread resulting in a predisposition to severe lung pathology. This response is similar to severe human respiratory paramyxovirus infections, which will serve as a model for the elucidation of hyper-immune inflammatory response that result to severe immunopathology in respiratory viral infections. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.