Mechanisms of differential growth of heart ventricles in newborn pigs.
Mechanisms of differential growth of heart ventricles in newborn pigs.
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新生猪心室差异生长的机制。
DOI：
10.1161/01.res.64.2.360
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发表时间：
1989
影响因子：
20.1
通讯作者：
Morgan,HE
中科院分区：
文献类型：
--
作者：
Peterson,CJ;Whitman,V;Watson,PA;Schuler,HG;Morgan,HE
在新生猪生命的前 10 天内，左心室游离壁 (LVFW) 的生长速度大约是右心室游离壁 (RVFW) 的三倍。更快的生长与总 RNA 和信使 RNA 的比例增加有关。这些发现表明，更大的蛋白质合成能力是加速生长的主要因素。尽管生长较快，但仔猪的心脏核糖体亚基含量高于 60 日龄猪或成年大鼠，这表明肽链起始速率比延伸速率相对较慢。当对 5 日龄猪的心脏进行体外灌注时，LVFW 中的蛋白质合成速度比 RVFW 中更快。在不添加胰岛素的情况下，较高的速率是由于更高的效率和更大的蛋白质合成能力。在激素存在的情况下，与 RVFW 相比，LVFW 的蛋白质合成率更高，因此容量更大。
The left ventricular free wall (LVFW) grew approximately three times faster than the right ventricular free wall (RVFW) during the first 10 days of life in neonatal pigs. Faster growth was associated with proportional increases in total RNA and messenger RNA. These findings indicated that greater capacity for protein synthesis was a major factor in accelerated growth. Despite faster growth, heart content of ribosomal subunits was higher in piglets than in 60-day-old pigs or adult rats, suggesting a relatively slower rate of peptide chain initiation than elongation. When hearts from 5-day-old pigs were perfused in vitro, protein synthesis was more rapid in the LVFW than in the RVFW. In the absence of added insulin, the higher rate was due to both greater efficiency and greater capacity for protein synthesis. In the presence of the hormone, greater capacity was responsible for the increased rate of protein synthesis in the LVFW as compared with the RVFW.
生物学和病理学中的血小板
DOI：
--
发表时间：
1981
期刊：
影响因子：
--
作者：
J. L. Gordon
通讯作者：
J. L. Gordon