Differentially Addressable Cavities within Metal-Organic Cage-Cross-Linked Polymeric Hydrogels
Differentially Addressable Cavities within Metal-Organic Cage-Cross-Linked Polymeric Hydrogels
复制标题
DOI：
10.1021/jacs.5b05507
复制
发表时间：
2015-08-05
影响因子：
15
通讯作者：
Nitschke, Jonathan R.
中科院分区：
文献类型：
--
作者：
Foster, Jonathan A.;Parker, Richard M.;Nitschke, Jonathan R.
在这里，我们报告了一类新的水凝胶形成的聚合物是通过子组件自组装金属有机笼交联。选择性地将客体分子包裹在笼中。在水凝胶内产生两个不同的内相，这使得相关分子的释放曲线可以根据其能力进行对比，以封装在笼内。通过基于液滴的微流体方法将水凝胶制造成微粒，并证明其对各种刺激（包括酸和竞争性胺或醛子组分）有响应，从而允许货物的触发释放。
Here we report a new class of hydrogels formed by polymers that are cross-linked through subcomponent self-assembled metal organic cages. Selective encapsulation of guest molecules with in the cages. creates two distinct internal phases within the hydrogel, which allows for contrasting release profiles of related, molecules depending on their aptitude, for encapsulation within the cages. The hydrogels were fabricated into microparticles via a droplet-based microfluidic approach and proved responsive to a variety, of stimuli, including acid and competing amine or aldehyde subcomponents, allowing for the triggered release of cargo.