O-DEMETHYLPAULOMYCIN-A AND O-DEMETHYLPAULOMYCIN-B, U-77,802 AND U-77,803, PAULOMENOL-A AND PAULOMENOL-B, NEW METABOLITES PRODUCED BY STREPTOMYCES-PAULUS
O-DEMETHYLPAULOMYCIN-A AND O-DEMETHYLPAULOMYCIN-B, U-77,802 AND U-77,803, PAULOMENOL-A AND PAULOMENOL-B, NEW METABOLITES PRODUCED BY STREPTOMYCES-PAULUS
复制标题
DOI：
10.7164/antibiotics.41.1316
复制
发表时间：
1988-10-01
影响因子：
3.3
通讯作者：
SHILLIDAY, FB
中科院分区：
文献类型：
--
作者：
ARGOUDELIS, AD;BACZYNSKYJ, L;SHILLIDAY, FB
O-去甲基保洛霉素A（C33 H44 N2 O 17 S），O-去甲基保洛霉素B（C32H42N2O17s），paulomenol A（C20 H43 NO10），paulomenol B（C28 H41 NO10）和保霉素A的硫化氢加合物（U-77，802，C34 H48 N2 O 17 S2）和保霉素B（U-77，803，C33 H46 N2 O 17 S2）已从Streptomyces paulus菌株273的发酵物中分离。通过~ 1H和~（13）C NMR、快原子轰击质谱技术和降解研究确定了这些化合物的结构。这些新代谢物的抗菌特性与保罗霉素A和B有关（J. Antibiotics 35：285 apprx. 294，1982），简要讨论。
O-Demethylpaulomycin A (C33H44N2O17S), O-demethylpaulomycin B (C32H42N2O17s), paulomenol A (C20H43NO10), paulomenol b (C28H41NO10), and the hydrogen sulfide adducts of paulomycin A (U-77,802, C34H48N2O17S2), and paulomycin B (U-77,803, C33H46N2O17S2) have been isolated from fermentations of Streptomyces paulus strain 273. The structure of these compounds was determined by 1H and 13C NMR and fast atom bombardment mass spectrum spectroscopic techniques and degradative studies. The antibacterial properties of these new metabolites, which are related to paulomycins A and B (J. Antibiotics 35:285 .apprx. 294, 1982), are briefly discussed.