Insights from neuropsychology: pinpointing the role of the posterior parietal cortex in episodic and working memory.
Insights from neuropsychology: pinpointing the role of the posterior parietal cortex in episodic and working memory.
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DOI：
10.3389/fnint.2012.00031
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发表时间：
2012
影响因子：
3.5
通讯作者：
Berryhill ME
中科院分区：
文献类型：
--
作者：
Berryhill ME
后顶叶皮层（PPC）在各种形式的记忆中的作用是当前认知神经科学领域的一个热门话题。这个巨大的皮层区域与影响记忆处理的各个阶段（编码、维持和提取）的各种记忆功能有关。然而，PPC在记忆中的确切作用仍然是神秘和有争议的。在理解PPC功能方面的进展将要求研究人员以收敛的方式从多种实验技术中整合发现，而不是强调特定类型的数据。为了促进这一过程，在这里，我们回顾了人类神经心理学研究的结果，并检查PPC损伤后对记忆的影响。最近基于患者的研究结果已经调查了两个典型的分离领域：工作记忆（WM）和情景记忆。总结了单侧和双侧PPC病变患者参与者进行不同实验范式的结果。然后将这些发现与其他技术（包括神经刺激（TMS和tDCS））和有影响力且更丰富的功能性神经影像学文献的发现相关。然后，我们审查的优点和缺点的假设提出帐户PPC功能在这些形式的记忆。最后，我们解决了哪些缺失的证据需要澄清PPC在记忆中的作用。
The role of posterior parietal cortex (PPC) in various forms of memory is a current topic of interest in the broader field of cognitive neuroscience. This large cortical region has been linked with a wide range of mnemonic functions affecting each stage of memory processing: encoding, maintenance, and retrieval. Yet, the precise role of the PPC in memory remains mysterious and controversial. Progress in understanding PPC function will require researchers to incorporate findings in a convergent manner from multiple experimental techniques rather than emphasizing a particular type of data. To facilitate this process, here, we review findings from the human neuropsychological research and examine the consequences to memory following PPC damage. Recent patient-based research findings have investigated two typically disconnected fields: working memory (WM) and episodic memory. The findings from patient participants with unilateral and bilateral PPC lesions performing diverse experimental paradigms are summarized. These findings are then related to findings from other techniques including neurostimulation (TMS and tDCS) and the influential and more abundant functional neuroimaging literature. We then review the strengths and weaknesses of hypotheses proposed to account for PPC function in these forms of memory. Finally, we address what missing evidence is needed to clarify the role(s) of the PPC in memory.