Light-dependent compartmentalization of transducin in rod photoreceptors
Light-dependent compartmentalization of transducin in rod photoreceptors
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DOI：
10.1007/s12035-008-8015-2
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发表时间：
2008-02-01
影响因子：
5.1
通讯作者：
Artemyev, Nikolai O.
中科院分区：
文献类型：
--
作者：
Artemyev, Nikolai O.
三种主要的视觉信号蛋白，转导蛋白、阻滞蛋白和恢复蛋白以光依赖的方式在视杆光感受器的外段和内室之间进行双向易位。蛋白质的光依赖性易位被认为有助于光感受器细胞的适应和神经保护。光控制蛋白易位的潜在生理意义和机制是当前讨论的中心。在本文中，我概述了在理解转导蛋白的双向易位的机制和其稳态分布的决定因素在黑暗和适应光的感光细胞的最新进展。
Three major visual signaling proteins, transducin, arrestin, and recoverin undergo bidirectional translocations between the outer segment and inner compartments of rod photoreceptors in a light-dependent manner. The light-dependent translocation of proteins is believed to contribute to adaptation and neuroprotection of photoreceptor cells. The potential physiological significance and mechanisms of light-controlled protein translocations are at the center of current discussion. In this paper, I outline the latest advances in understanding the mechanisms of bidirectional translocation of transducin and determinants of its steady-state distribution in dark- and light-adapted photoreceptor cells.