Ferrostatin-1 alleviated TNBS induced colitis via the inhibition of ferroptosis.
Ferrostatin-1 alleviated TNBS induced colitis via the inhibition of ferroptosis.
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Ferrostatin-1 通过抑制铁死亡来缓解 TNBS 诱导的结肠炎。
DOI：
10.1016/j.bbrc.2021.08.018
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Shengtao Zhu
中科院分区：
文献类型：
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作者：
Junxuan Xu;Si Liu;Zilu Cui;Xingyu Wang;T. Ning;Tiange Wang;Nan Zhang;Si;L. Min;Shutian Zhang;Chunnan Liang;Shengtao Zhu
炎症性肠病（IBD）是一种主要累及肠道的慢性复发性、危及生命的炎症性疾病，包括溃疡性结肠炎（UC）和克罗恩病（CD）。中重度IBD的主流治疗方法是使用免疫抑制剂。但是，它遇到了药物耐受性和重大不良事件的问题。因此，识别IBD中涉及的新信号通路对于满足IBD患者未满足的治疗需求是必要的。铁与IBD之间存在一定的联系，并有文献报道UC可引起铁凋亡。然而，作为IBD的另一个重要亚型，CD是否也发生铁凋亡尚不清楚。本研究发现，CD的发生与机体铁代谢失调、脂质过氧化和氧化还原稳态失调有关，铁蛋白抑制剂Ferrostatin-1可减轻TNBS诱导的CD样结肠炎小鼠的病理表型。我们的研究结果为CD的治疗提供了一种新的有希望的治疗策略，特别是对于那些对现有免疫抑制剂药物耐受的患者。
Inflammatory bowel disease (IBD), consisting of ulcerative colitis (UC) and Crohn's disease (CD), is a chronic relapsing and life-threatening inflammatory disorder that mainly affect the intestinal tract. The mainstream therapies for moderate to severe IBD lie in the use of immunosuppressive agents. However, it encountered the problem of drug tolerance and significant adverse events. Therefore, identifying novel signal pathways involved in IBD is necessary to satisfy the unmet treatment needs of IBD patients. There existed some hints between iron and IBD, and was reported that ferroptosis induced in UC. However, as another important subtype of IBD, whether ferroptosis also occurred in CD remains unclear. In this study, we found that the dysregulation of iron, lipid peroxidation and redox homeostasis were involved in CD; the administration of ferroptosis inhibitor Ferrostatin-1 could alleviate pathological phenotypes of TNBS induced CD-like colitis in mice. Our results provide a new hopeful therapeutic strategy in treating CD, especially for those who suffered from the tolerance of existing immunosuppressive agent drugs.