Efficacy of olanexidine gluconate in canine superficial pyoderma: a randomised, single‐blinded controlled trial
Efficacy of olanexidine gluconate in canine superficial pyoderma: a randomised, single‐blinded controlled trial
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葡萄糖酸奥兰西丁治疗犬浅表脓皮病的疗效：一项随机、单盲对照试验
DOI：
10.1111/vde.13038
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发表时间：
2021
影响因子：
1.4
通讯作者：
Iyori Keita
中科院分区：
文献类型：
--
作者：
Hsiao Yun‐Hsia;Imanishi Ichiro;Iyori Keita
背景局部治疗对犬浅表性脓疡的治疗是有益的。一种新的抗菌剂，olanexidine葡萄糖酸盐，已成为最近可用于人类，其疗效为犬脓癣局部therapeutic是unknow. The的olanexidine的抗菌效果进行了评估，使用最小抑菌浓度（MIC）towardsStaphylococcus pseudintermedius。此外，其临床疗效在犬浅表性脓疡进行了评估，在一个随机，单盲study.AnimalsTwenty-eight客户拥有的狗异位性皮炎和浅表性脓疡。通过96孔肉汤微量稀释法连续稀释的假中间体分离物（n=73）。关于临床试验，将所有招募的犬随机分为两组;一组每日一次使用1.5%奥拉西定喷雾剂治疗，另一组每周一次使用3%氯己定洗发剂治疗，共2次。根据日本动物抗菌药物学会的指南，在第0天和第14天进行临床评估。伪中间型（MRSP）和甲氧西林敏感型。假中间肌（MSSP）分别为0.23 μg/ml和0.24 μg/ml（P =0.9）。在临床试验中，奥兰西定和氯己定显示出显着改善临床表现相比basel.Conclusions和临床重要性奥兰西定显示出类似的疗效与氯己定（P=0.73）。此外，MIC对S. pseudintermedius表明高杀菌活性，这得到了奥兰西定的局部有效性的支持。
BackgroundTopical treatments can be beneficial for managing canine superficial pyoderma. A novel antiseptic agent, olanexidine gluconate, has become available recently for use in humans, and its efficacy for canine pyoderma as topical therapy is unknown.ObjectiveThe antimicrobial effect of olanexidine was evaluated using minimal inhibitory concentration (MIC) towardsStaphylococcus pseudintermedius. Furthermore, its clinical efficacy in canine superficial pyoderma was assessed in a randomized, single‐blinded study.AnimalsTwenty‐eight client‐owned dogs with atopic dermatitis and superficial pyoderma.Methods and materialsThe MIC of olanexidine was determined forS. pseudintermediusisolates (n=73) by serial dilution of 96‐well broth microdilution method. Regarding the clinical trial, all recruited dogs were randomized into two groups; one treated with 1.5% olanexidine spray once daily and the other with a 3% chlorhexidine shampoo once a week for 2 times, respectively. Clinical assessment was performed at days 0 and 14 according to the guidelines of the Japanese Society of Antimicrobials for Animals.ResultsThe MIC values for methicillin‐resistantS. pseudintermedius(MRSP) and methicillin‐sensitiveS. pseudintermedius(MSSP) were 0.23 μg/ml and 0.24 μg/ml (P =0.9), respectively. In clinical trial, olanexidine and chlorhexidine showed substantial improvement in clinical presentation compared to the baseline.Conclusions and clinical importanceOlanexidine showed comparable efficacy to chlorhexidine (P=0.73). Moreover, the MIC againstS. pseudintermediusindicated high bactericidal activity, which was supported by the topical effectiveness of olanexidine.