Experience-dependent modification of primary sensory synapses in the mammalian olfactory bulb
Experience-dependent modification of primary sensory synapses in the mammalian olfactory bulb
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DOI：
10.1523/jneurosci.0664-07.2007
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发表时间：
2007-08-29
影响因子：
5.3
通讯作者：
Murthy, Venkatesh N.
中科院分区：
文献类型：
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作者：
Tyler, William J.;Petzold, Gabor C.;Murthy, Venkatesh N.
传统上，神经回路中的经验依赖性变化是通过感觉输入下游的几个突触来研究的。经验是否能改变初级感觉突触的强度，目前仍不清楚。为了解决这个问题，我们研究了气味剥夺对大鼠嗅球中嗅觉感觉轴突突触的影响。气味剥夺引发了增加的概率谷氨酸释放的嗅觉感觉神经元突触。去甲肾上腺素还增加了AMPA和NMDA型谷氨酸受体介导的量子突触电流的振幅，以及这些受体在肾小球区域的丰度。我们的研究结果表明，感觉经验是能够调节突触强度在环境和生物体之间的信息传递的最早阶段。这种代偿性的经验依赖性变化可能代表了感觉增益控制的机制。
Experience-dependent changes in neural circuits have traditionally been investigated several synapses downstream of sensory input. Whether experience can alter the strength of primary sensory synapses remains mostly unknown. To address this issue, we investigated the consequences of odor deprivation on synapses made by olfactory sensory axons in the olfactory bulb of rats. Odor deprivation triggered an increase in the probability of glutamate release from olfactory sensory neuron synapses. Deprivation also increased the amplitude of quantal synaptic currents mediated by AMPA- and NMDA-type glutamate receptors, as well as the abundance of these receptors in the glomerular region. Our results demonstrate that sensory experience is capable of modulating synaptic strength at the earliest stages of information transfer between the environment and an organism. Such compensatory experience-dependent changes may represent a mechanism of sensory gain control.