Lateralisation of auditory processing in Down syndrome: A study of T-complex peaks Ta and Tb
Lateralisation of auditory processing in Down syndrome: A study of T-complex peaks Ta and Tb
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DOI：
10.1016/j.biopsycho.2008.04.003
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发表时间：
2008-10-01
影响因子：
2.6
通讯作者：
Bishop, Dorothy Vera Margaret
中科院分区：
文献类型：
--
作者：
Groen, Margriet Anna;Alku, Paavo;Bishop, Dorothy Vera Margaret
长期以来，人们一直认为异常的大脑偏侧化可能是导致唐氏综合症的语言问题的基础，但迄今为止，只有行为方面的证据被提供。我们使用的听觉事件相关电位Ta和Tb的T-复杂的语言（元音）和非语言（简单和复杂的音调）的声音在唐氏综合征儿童和年龄匹配的典型发展的儿童调查偏侧处理。我们还探讨了与言语和语言能力的联系。虽然在Ta和Tb的变化，以响应刺激的复杂性和“言语”的增加是相似的跨组，Tb的峰值被推迟在儿童唐氏综合征的条件。此外，显着的差异，Ta潜伏期和Tb振幅的偏侧化的模式中观察到唐氏综合征的儿童，在响应语音和非语音的声音。Ta和Tb特征与DS儿童的言语和语言能力之间没有关联。(C)2008 Elsevier B. V.保留所有权利。
It has long been argued that abnormal cerebral lateralisation might underlie the language problems that characterise Down syndrome, but to date only behavioural evidence has been provided. We used the auditory event-related potentials Ta and Tb of the T-complex to investigate lateralised processing of speech (vowels) and non-speech (simple and complex tones) sounds in children with Down syndrome and age-matched typically developing children. We also explored associations with speech and language abilities. Although changes in the Ta and Tb in response to increases in stimulus complexity and 'speechness' were similar across group, the Tb peak was delayed in children with Down syndrome across conditions. In addition, marked differences in the patterns of lateralisation of Ta latency and Tb amplitude were observed in children with Down syndrome, in response to both speech and non-speech sounds. No associations were found between Ta and Tb characteristics and speech and language abilities in children with DS. (C) 2008 Elsevier B.V. All rights reserved.