Acute cholestatic hepatitis induced by fenofibrate
Acute cholestatic hepatitis induced by fenofibrate
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DOI：
10.1111/j.1365-2710.2009.01029.x
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发表时间：
2009-10-01
影响因子：
2
通讯作者：
Urbanek, K.
中科院分区：
文献类型：
--
作者：
Hajdu, D.;Aiglova, K.;Urbanek, K.
我们报告一例可能由非诺贝特引起的急性肝损伤.一名50岁女性，无肝病史，在非诺贝特治疗第二周发生胆汁淤积性肝炎。入院时实验室检查显示血清胆红素534中心点0 mcmol/L（结合444中心点0），碱性磷酸酶（AP）8中心点76，γ-谷氨酰转肽酶（GGT）20中心点92，丙氨酸氨基转移酶（ALT）2中心点6，天冬氨酸氨基转移酶（AST）3中心点64 mckat/L。停用非诺贝特和熊去氧胆酸（每日750 mg）给药后，迅速获得了良好的结局。
P>We report a case of acute liver injury probably due to fenofibrate. A 50-year-old female without a history of liver disease developed cholestatic hepatitis during her second week of fenofibrate treatment. Laboratory tests on admission showed serum bilirubin 534 center dot 0 mcmol/L (conjugated 444 center dot 0), alkaline phosphatase (AP) 8 center dot 76, gamma-glutamyl traspeptidase (GGT) 20 center dot 92, alanine aminotransferase (ALT) 2 center dot 6, aspartate aminotransferase (AST) 3 center dot 64 mckat/L. Fenofibrate withdrawal and ursodeoxycholic acid (750 mg daily) administration was rapidly followed by a favourable outcome.