THE RELATIONSHIP BETWEEN VITAMIN-A DEFICIENCY AND ESTROGEN IN PRODUCING UTERINE METAPLASIA IN THE RAT
THE RELATIONSHIP BETWEEN VITAMIN-A DEFICIENCY AND ESTROGEN IN PRODUCING UTERINE METAPLASIA IN THE RAT
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DOI：
10.1002/ar.1091240402
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发表时间：
1956-01-01
影响因子：
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通讯作者：
BO, WJ
中科院分区：
文献类型：
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作者：
BO, WJ
维生素A缺乏大鼠子宫上皮化生可见于正常动物。作者最近报道，去卵巢的缺陷动物不会发生子宫化生。结果表明，卵巢激素，可能是雌激素，必须为子宫组织提供条件，以便在这种维生素缺乏症中发生化生。这项实验旨在显示雌激素是否对卵巢切除维生素A缺乏大鼠的子宫化生起关键作用。在缺乏维生素A饮食和雌激素治疗的去卵巢大鼠中，观察到显著的子宫化生变化。在去卵巢的动物中，没有观察到适当饮食和雌激素治疗的变化。结果表明，雌激素有效地替代了卵巢在子宫上皮化生中的作用，提示雌激素在非去卵巢维生素A缺乏大鼠子宫上皮化生中起一定作用。
Metaplasia of uterine epithelium in vitamin A deficient rats has been observed to occur in intact animals. The author has recently reported that uterine metaplasia did not occur in ovariecto-mized deficient animals. The results suggest that an ovarian hormone, probably estrogen, must condition the uterine tissue for metaplasia to occur in this vitamin deficiency. The experiment was designed to show whether or not estrogen is essential to produce uterine metaplasia in ovariectomized vitamin A deficient rats. Pronounced metaplastic changes of the uterus were observed in the ovariectomized rats on a vitamin A deficient diet and treated with estrogen. No changes were observed in the ovariectomized animals on an adequate diet and treated with estrogen. The observations show that estrogen effectively substitutes for the ovary in the production of metaplasia of uterine epithelium and suggest that estrogen plays a role in producing uterine metaplasia in non-ovariectomized vitamin A deficient rats.