Gene or size: Metabolic rate and body temperature in obese growth hormone-deficient dwarf mice
Gene or size: Metabolic rate and body temperature in obese growth hormone-deficient dwarf mice
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DOI：
10.1038/oby.2004.188
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发表时间：
2004-09-01
期刊：
影响因子：
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通讯作者：
Heldmaier, G
中科院分区：
文献类型：
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作者：
Meyer, CWE;Klingenspor, M;Heldmaier, G
目的：SMA 1小鼠生长激素基因存在错义突变，导致半显性侏儒症和肥胖。在这项研究中，基本的热和代谢特性的SMA 1小鼠进行了检查，以检测代谢的改变，可以支持的accession of excess fat.Research Methods和Procedures：基础和静息代谢率（RMR）在野生型和SMA 1（sma 1/+和sma 1/sma 1）小鼠间接测热法测定。使用腹腔内植入的温度敏感发射器记录体温（T-b），并通过DXA.Results测定身体组成：SMA 1小鼠具有成比例的较低基础和静息代谢率、较高的体质量（BM）特异性RMR和较高的较低临界温度，并显示Tb在sma 1/+中降低0.4 degreesC和在sma 1/sma 1中降低0.9 degreesC。分析突变小鼠BM和能量消耗的基因效应必须考虑BM和代谢率之间的异速生长关系。除Tb外，SMA 1中观察到的所有代谢改变均反映了尺寸减小。
Objective: SMA1 mice carry a missense mutation in the growth hormone gene that leads to semidominant dwarfism and obesity. In this study, the basic thermal and metabolic properties of SMA1 mice were examined to detect metabolic alterations that can support the accretion of excess fat.Research Methods and Procedures: Basal and resting metabolic rates (RMRs) in wild-type and SMA1 (sma1/+ and sma1/sma1) mice were determined by indirect calorimetry. Body temperature (T-b) was recorded using intraperitoneally implanted temperature-sensitive transmitters, and body composition was determined by DXA.Results: SMA1 mice have proportionally lower basal and resting metabolic rates, higher body mass (BM)-specific RMRs, and a higher lower critical temperature, and display a decrease in Tb by 0.4 degreesC in sma1/+ and 0.9 degreesC in sma1/sma1.Discussion: The analysis of gene effects on BM and energy expenditure in mouse mutants must consider the appropriate allometric relationship between BM and metabolic rate. With the exception of Tb, all metabolic alterations observed in SMA1 reflect reduced size.