A fibroadenoma with a t(4;12) (q27;q15) affecting the HMGI-C gene, a member of the high mobility group protein gene family
A fibroadenoma with a t(4;12) (q27;q15) affecting the HMGI-C gene, a member of the high mobility group protein gene family
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DOI：
10.1007/bf01806149
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发表时间：
1996-01-01
影响因子：
3.8
通讯作者：
Bullerdiek, J
中科院分区：
文献类型：
--
作者：
Staats, B;Bonk, U;Bullerdiek, J
一个乳腺导管内纤维腺瘤显示克隆性染色体畸变t（4;12）（q27;q15）作为唯一的细胞遗传学异常的描述。为了在分子水平上缩小12号染色体上的断裂点区域，我们用来自跨越12 q14 -15区域的YAC重叠群的粘粒池进行荧光原位杂交（FISH）分析。我们能够将断裂点缩小到属于HMGI-C基因的约230 kb片段，该片段位于最近指定为MAR（多重畸变区）的区域内。其他常见的良性实体瘤，如脂肪瘤、子宫平滑肌瘤和多形性腺瘤的染色体断裂点聚集在该基因的第三内含子内。
An intracanalicular fibroadenoma of the breast showing a clonal chromosomal aberration t(4;12) (q27;q15) as the sole cytogenetic abnormality is described. In order to narrow down the breakpoint region on chromosome 12 on the molecular level we performed fluorescence in situ hybridization (FISH) analysis with a cosmid pool originating from a YAC-contig overspanning part of the region 12q14-15. We were able to narrow down the breakpoint to an approximately 230kb fragment belonging to the HMGI-C gene which maps within an area recently designated as MAR (Multiple Aberration Region). The chromosomal breakpoints of other frequent benign solid tumors, i.e. lipomas, uterine leiomyomas, and pleomorphic adenomas are clustered within the third intron of that gene.