Pulmonary adenocarcinomas with enteric differentiation - Histologic and immunohistochemical characteristics compared with metastatic colorectal cancers and usual pulmonary adenocarcinomas
Pulmonary adenocarcinomas with enteric differentiation - Histologic and immunohistochemical characteristics compared with metastatic colorectal cancers and usual pulmonary adenocarcinomas
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DOI：
10.1097/01.pas.0000160438.00652.8b
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发表时间：
2005-05-01
影响因子：
5.6
通讯作者：
Ishikawa, Y
中科院分区：
文献类型：
--
作者：
Inamura, K;Satoh, Y;Ishikawa, Y
原发性肺腺癌肠分化（PAED）主要由高柱状细胞组成，与肠上皮和结直肠癌相似。在这项研究中，我们使用针对CDX-2、细胞角蛋白7 （CK7）、细胞角蛋白20 （CK20）、TTF-1、表面活性载蛋白A （SP-A）、Napsin A和MUC2的抗体，分析了7例PAEDs与14例转移性结直肠癌（mcr）和30例普通肺腺癌（PACs）的免疫染色谱。PAEDs中CDX-2、CK7、CK20、TTF-1、SP-A、Napsin A、MUC2的阳性率分别为71%、100%、43%、43%、14%、0%、43%；mcr为100%、0%、86%、0%、0%、0%和57%；3%、100%、0%、93%、73%、90%、0%。正如预期的那样，在PAEDs中检测到CDX-2、CK20和MUC2的免疫反应性。观察到的TTF-1、SP-A和Napsin A免疫反应性的降低或丧失表明，尽管CK7的表达保持不变，但这些病变显示出与其肺表型的转移。结果表明，CK7和CK20可能是区分paed和mcr的有用标记物。
Primary pulmonary adenocarcinomas with enteric differentiation (PAED) are mainly composed of tall-columnar cells that show similarity to intestinal epithelia and colorectal carcinomas. In this study, we analyzed the immunostaining profiles of 7 PAEDs in comparison with 14 metastatic colorectal carcinomas (MCRs) and 30 usual pulmonary adenocarcinomas (PACs), using antibodies against CDX-2, cytokeratin 7 (CK7), cytokeratin 20 (CK20), TTF-1, surfactant apoprotein-A (SP-A), Napsin A, and MUC2. The positive rates for CDX-2, CK7, CK20, TTF-1, SP-A, Napsin A, and MUC2 were 71%,100%,43%, 43%,14%, 0%, and 43%, respectively, in the PAEDs; 100%, 0%, 86%, 0%, 0%, 0%, and 57% in the MCRs; 3%, 100%, 0%, 93%, 73%, 90%, and 0% in PACs. As expected, immunoreactivity of CDX-2, CK20, and MUC2 was detected in PAEDs. The observed decrease or loss of immunoreactivity for TTF-1, SP-A, and Napsin A indicates that these lesions demonstrate a shift away from their pulmonary phenotype, although CK7 expression was retained. The results indicate that CK7 and CK20 may be useful markers for distinction of PAEDs from MCRs.