Consumption of animal foods and endometrial cancer risk: a systematic literature review and meta-analysis
Consumption of animal foods and endometrial cancer risk: a systematic literature review and meta-analysis
复制标题
DOI：
10.1007/s10552-007-9038-0
复制
发表时间：
2007-11-01
影响因子：
2.3
通讯作者：
McCullough, Marjorie L.
中科院分区：
文献类型：
--
作者：
Bandera, Elisa V.;Kushi, Lawrence H.;McCullough, Marjorie L.
本文总结并量化了目前有关动物产品饮食摄入与子宫内膜癌的证据。进行文献检索以确定2006年12月之前发表的经同行评审的手稿。来自3项队列研究和16项病例对照研究的22篇论文被确定。其中一项队列研究只评估油炸肉，另一项只评估牛奶的摄入量；他们没有被纳入我们的荟萃分析。确定的第三项队列研究没有显示暴露水平，因此不能纳入剂量-反应荟萃分析。这项队列研究没有显示与肉类或红肉的消费有关。评估这些食物的病例对照研究的随机效应剂量反应汇总估计为每100克/天总肉1.26 (95% CI: 1.03-1.54)，每100克/天红肉1.51 (95% CI: 1.19-1.93)，每100克/天家禽1.03 (95% CI: 0.32-3.28)，每100克/天鱼1.04 (95% CI: 0.55-1.98)，每份乳制品0.97 （95% CI: 0.93-1.01）。我们基于病例对照数据的荟萃分析表明，肉类消费，尤其是红肉，会增加子宫内膜癌的风险。目前的文献不支持与乳制品的联系，而家禽，鱼类和蛋类的证据不一致。需要更多的研究，特别是前瞻性研究。
This article summarizes and quantifies the current evidence relating dietary intake of animal products and endometrial cancer. Literature searches were conducted to identify peer-reviewed manuscripts published up to December 2006. Twenty-two manuscripts from three cohort studies and 16 case-control studies were identified. One of these cohort studies evaluated only fried meat and another only milk consumption; they were not included in our meta-analyses. The third cohort study identified did not present exposure levels and could not be included in dose-response meta-analysis. This cohort study did not show an association with meat or red meat consumption. Random-effects dose-response summary estimates for case-control studies evaluating these foods were 1.26 (95% CI: 1.03-1.54) per 100 g/day of total meat, 1.51 (95% CI: 1.19-1.93) per 100 g/day of red meat, 1.03 (95% CI: 0.32-3.28) per 100 g/day of poultry, 1.04 (95% CI: 0.55-1.98) per 100 g/day of fish, and 0.97 (95% CI: 0.93-1.01) per serving of dairy. Our meta-analysis, based on case-control data, suggests that meat consumption, particularly red meat, increases endometrial cancer risk. The current literature does not support an association with dairy products, while the evidence is inconsistent for poultry, fish, and eggs. More studies, particularly prospective studies, are needed.