Elastic instability in growing yeast colonies
Elastic instability in growing yeast colonies
复制标题
DOI：
10.1016/s0006-3495(04)74327-1
复制
发表时间：
2004-05-01
影响因子：
3.4
通讯作者：
Brenner, MP
中科院分区：
文献类型：
--
作者：
Nguyen, B;Upadhyaya, A;Brenner, MP
细胞之间的差异粘附被认为是组织形成背后的主要驱动力。其想法是，细胞聚集体可以最大限度地减少细胞表面之间的总体粘附能。我们证明在一个模型实验系统中，存在的条件下，缓慢生长的组织不减少这种粘合剂的能量。一个数学模型表明，球形的不稳定性是由弹性能和表面能之间的竞争引起的。
The differential adhesion between cells is believed to be the major driving force behind the formation of tissues. The idea is that an aggregate of cells minimizes the overall adhesive energy between cell surfaces. We demonstrate in a model experimental system that there exist conditions where a slowly growing tissue does not minimize this adhesive energy. A mathematical model demonstrates that the instability of a spherical shape is caused by the competition between elastic and surface energies.