N-ACETYLSEROTONIN IN THE CENTRAL NERVOUS-SYSTEM
N-ACETYLSEROTONIN IN THE CENTRAL NERVOUS-SYSTEM
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DOI：
10.1016/0278-5846(84)90003-4
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发表时间：
1984-01-01
影响因子：
5.6
通讯作者：
NILES, LP
中科院分区：
文献类型：
--
作者：
BROWN, GM;PULIDO, O;NILES, LP
1. n -乙酰5 -羟色胺已被免疫组织化学鉴定在特定的大脑区域分离褪黑素和5 -羟色胺。n -乙酰- 5 -羟色胺广泛分布于脑干、小脑和海马内，在脑干中包含于网状形成核和运动核内。像5 -羟色胺一样，n -乙酰5 -羟色胺似乎来源于色氨酸，因为色氨酸羟化酶抑制导致脑和血液中非活性n -乙酰5 -羟色胺的降低。肾上腺素能药物通过肾上腺素能激动剂影响n -乙酰- 5 -羟色胺神经元，导致免疫反应性n -乙酰- 5 -羟色胺升高。经气相色谱、质谱和放射免疫分析证实，n -乙酰- 5 -羟色胺在脑中的存在。在这一点上，人们对n -乙酰血清素在大脑中的可能作用知之甚少。在海马中，n -乙酰5 -羟色胺存在于颗粒细胞中，其外观与颗粒细胞的外观相似。氚化n -乙酰5 -羟色胺的高亲和力结合在大脑和大脑的各个区域被发现，这种放射性配体似乎标记了5 -羟色胺能受体。在海马切片上进行的初步离子电泳研究表明，n -乙酰5 -羟色胺对谷氨酸诱导的锥体细胞放电有抑制作用。综上所述，这些发现表明n -乙酰血清素在中枢神经系统中的作用可能不同于褪黑素的前体。如果这个假设是正确的，它将表明吲哚胺与儿茶酚胺有某些相似之处。因此，对于儿茶酚胺，多巴胺，去甲肾上腺素和肾上腺素形成一个合成序列，但作为神经递质和/或激素具有独立的作用。三种吲哚胺- 5 -羟色胺、n -乙酰- 5 -羟色胺和褪黑素也形成一个合成序列，这三种物质也可能作为神经递质和/或激素具有独立的作用。
1. N-acetylserotonin has been identified by immunohistochemistry in specific brain areas separate from melatonin and serotonin. N-acetylserotonin is widely distributed within the brain stem, cerebellum and hippocampus and in the brain stem it is contained within reticular formation nuclei and motor nuclei. Like serotonin, N-acetylserotonin appears to be derived from tryptophan as tryptophan hydroxylase inhibition leads to a lowering in innunoreactive N-acetylserotonin in brain and blood. Beta adrenergic drugs influence N-acetylserotonin neurons with beta adrenergic agonists causing a rise in immunoreactive N-acetylserotonin. The presence of N-acetylserotonin in brain has been confirmed by gas chromatography, mass spectrometry and radioimmunoassay.2. At this point little is known of the possible role of N-acetylserotonin in the brain. In the hippocampus N-acetylserotonin is present in granule cells and its appearance parallels the appearance of those cells. High affinity binding of tritiated N-acetylserotonin is found in brain and in various brain areas and this radioligand appears to label serotonergic receptors. Preliminary iontophoretic studies performed on hippocampal slices indicate an inhibitory action of N-acetylserotonin on glutamate induced firing of pyramidal cells.3. Taken together these findings suggest that N-acetylserotonin may have a role in the central nervous system distinct from that of being a precursor for melatonin. If this hypothesis is correct it would suggest that indoleamines have certain similarities to catecholamines. Thus for the catecholamines, dopamine, norepinephrine and epinephrine form a synthetic sequence and yet have independent roles as neurotransmitters and/or hormones. The three indoleamines serotonin, N-acetylserotonin and melatonin also form a synthetic sequence and these three substances may also have independent roles as neurotransmitters and/or hormones.