FYVE-finger proteins--effectors of an inositol lipid.
FYVE-finger proteins--effectors of an inositol lipid.
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DOI：
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发表时间：
1999-12
影响因子：
4
通讯作者：
Harald Alfred Stenmark;R. Aasland
中科院分区：
文献类型：
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作者：
Harald Alfred Stenmark;R. Aasland
胞质蛋白与含有磷脂酰肌醇（PtdIns）磷酸化衍生物的特定细胞膜结合是重要细胞过程中的共同主题，如细胞骨架功能、受体信号传导和膜运输。最近，通过观察到一个保守的锌指状结构域（FYVE-finger）特异性地与这种脂质结合，出现了磷酸肌苷激酶产物PtdIns 3-磷酸（PtdIns(3)P）的几种潜在效应。本文综述了FYVE-PtdIns(3)P相互作用的结构基础，其在膜蛋白募集中的作用以及fyve -指蛋白在膜运输和其他细胞过程中的功能。
The binding of cytosolic proteins to specific intracellular membranes containing phosphorylated derivatives of phosphatidylinositol (PtdIns) is a common theme in vital cellular processes, such as cytoskeletal function, receptor signalling and membrane trafficking. Recently, several potential effectors of the phosphoinositide 3-kinase product PtdIns 3-phosphate (PtdIns(3)P) have emerged through the observation that a conserved zinc-finger-like domain, the FYVE-finger, binds specifically to this lipid. Here we review current knowledge about the structural basis for the FYVE-PtdIns(3)P interaction, its role in membrane recruitment of proteins and the functions of FYVE-finger proteins in membrane trafficking and other cellular processes.