Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression
Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression
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DOI：
10.1016/s0165-5728(01)00421-0
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发表时间：
2001-11-01
影响因子：
3.3
通讯作者：
Le, H
中科院分区：
文献类型：
--
作者：
Jyonouchi, H;Sun, SN;Le, H
我们确定了先天性和适应性免疫反应的儿童发育退化和自闭症谱系障碍（ASD，N = 71），发育正常的兄弟姐妹（N = 23），和控制（N = 17）。使用脂多糖（LPS）（一种先天免疫刺激剂），来自59/71（83.1%）ASD患者的外周血单核细胞（PBMC）产生的TNF-α、IL-1 β和/或IL-6的对照平均值（CM）高于对照PBMC产生的对照平均值（CM）> 2SD。ASD PBMC产生更高水平的促炎/反调节细胞因子没有刺激比对照组。使用植物血凝素（PHA）、破伤风、IL-12 p70和IL-18刺激物，来自47.9%至60%的ASD患者的PBMC产生高于TNF-α CM值的> 2 SD，这取决于刺激物。我们的研究结果表明，在一些ASD儿童中，先天性免疫反应过度可能在TNF-α的产生中最为明显。(C)2001 Elsevier Science B. V.保留所有权利。
We determined innate and adaptive immune responses in children with developmental regression and autism spectrum disorders (ASD, N = 71), developmentally normal siblings (N = 23), and controls (N = 17). With lipopolysaccharide (LPS), a stimulant for innate immunity, peripheral blood mononuclear cells (PBMCs) from 59/71 (83.1%) ASD patients produced > 2 SD above the control mean (CM) values of TNF-alpha, IL-1 beta, and/or IL-6 produced by control PBMCs. ASD PBMCs produced higher levels of proinflammatory/counter-regulatory cytokines without stimuli than controls. With stimulants of phytohemagglutinin (PHA), tetanus, IL-12p70, and IL-18, PBMCs from 47.9% to 60% of ASD patients produced > 2 SD above the CM values of TNF-alpha depending on stimulants. Our results indicate excessive innate immune responses in a number of ASD children that may be most evident in TNF-alpha production. (C) 2001 Elsevier Science B.V. All rights reserved.