A Supramolecular Hydrogel Based on Polyglycerol Dendrimer-Specific Amino Group Recognition
A Supramolecular Hydrogel Based on Polyglycerol Dendrimer-Specific Amino Group Recognition
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DOI：
10.1002/asia.201800559
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发表时间：
2018-07-04
影响因子：
4.1
通讯作者：
Ooya, Tooru
中科院分区：
文献类型：
--
作者：
Cho, Ik Sung;Ooya, Tooru
树突基超分子水凝胶在生物医学领域受到广泛关注。虽然生物相容性树状大分子被用于通过物理和/或化学交联制备水凝胶，但智能功能，如pH和分子控制仍未开发。在这里，我们提出了基于聚甘油树状大分子的超分子水凝胶的形成是由聚甘油树状大分子和乙二醇壳聚糖氨基之间的特定相互作用诱导的。通过混合两种水溶液实现凝胶化。通过改变聚甘油树状大分子的生成来控制水凝胶的形成。水凝胶呈ph依赖性溶胀；强酸性条件通过特异相互作用的解离诱导降解。由于乙二醇壳聚糖和l-精氨酸氨基的竞争性交换，它还表现出独特的l-精氨酸响应降解能力。这些聚甘油树突基的超分子特性允许在智能生物材料中的多模式应用。
Dendrimer-based supramolecular hydrogels have gained attention in biomedical fields. While biocompatible dendrimers were used to prepare hydrogels via physical and/or chemical crosslinking, smart functions such as pH and molecular control remain undeveloped. Here, we present polyglycerol dendrimer-based supramolecular hydrogel formation induced by a specific interaction between the polyglycerol dendrimer and an amino group of glycol chitosan. Gelation was achieved by mixing the two aqueous solutions. Hydrogel formation was controlled by varying the polyglycerol dendrimer generation. The hydrogel showed pH-dependent swelling; strongly acidic conditions induced degradation via dissociation of the specific interaction. It also showed unique l-arginine-responsive degradation capability due to competitive exchange of the amino groups of glycol chitosan and l-arginine. These polyglycerol dendrimer-based supramolecular characteristics allow multimodal application in smart biomaterials.