PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?
PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?
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DOI：
10.3389/fonc.2022.819128
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发表时间：
2022
影响因子：
4.7
通讯作者：
Zeng C
中科院分区：
文献类型：
--
作者：
Peng Y;Wang Y;Zhou C;Mei W;Zeng C
癌症是一个严重的公共卫生问题，是全球死亡的主要原因。这也是提高全世界预期寿命的一个障碍。此外，全球癌症发病率和死亡率的负担不断增加。目前的治疗选择对患者来说是不够的，肿瘤的复杂性和异质性需要定制药物或靶向治疗。识别潜在的癌症治疗靶点至关重要。PI 3 K/AKT/mTOR通路的异常激活在癌发生中具有重要作用。本文综述了PI 3 K/Akt/mTOR通路在肿瘤中的致癌性改变以及与PI 3 K/AKT/mTOR通路相关的各种肿瘤标志物，如细胞增殖、自噬、凋亡、血管生成、上皮-间质转化（EMT）和化疗耐药性。本文综述了PI 3 K/AKT/mTOR抑制剂的最新研究进展。总体而言，深入了解PI 3 K/AKT/mTOR通路与肿瘤发生之间的关联以及靶向PI 3 K/AKT/mTOR通路的治疗方法的开发将有助于做出临床决策。
Cancer is a severe public health issue that is a leading cause of mortality globally. It is also an impediment to improving life expectancy worldwide. Furthermore, the global burden of cancer incidence and death is continuously growing. Current therapeutic options are insufficient for patients, and tumor complexity and heterogeneity necessitate customized medicine or targeted therapy. It is critical to identify potential cancer therapeutic targets. Aberrant activation of the PI3K/AKT/mTOR pathway has a significant role in carcinogenesis. This review summarized oncogenic PI3K/Akt/mTOR pathway alterations in cancer and various cancer hallmarks associated with the PI3K/AKT/mTOR pathway, such as cell proliferation, autophagy, apoptosis, angiogenesis, epithelial-to-mesenchymal transition (EMT), and chemoresistance. Importantly, this review provided recent advances in PI3K/AKT/mTOR inhibitor research. Overall, an in-depth understanding of the association between the PI3K/AKT/mTOR pathway and tumorigenesis and the development of therapies targeting the PI3K/AKT/mTOR pathway will help make clinical decisions.
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影响因子：
45.3
作者：
Dreyling, Martin;Santoro, Armando;Zinzani, Pier Luigi
通讯作者：
Zinzani, Pier Luigi
影响因子：
11.5
作者：
Colombo, Ilaria;Genta, Sofia;Stathis, Anastasios
通讯作者：
Stathis, Anastasios
影响因子：
45.3
作者：
Bautista, Francisco;Paoletti, Xavier;Geoerger, Birgit
通讯作者：
Geoerger, Birgit
DOI：
10.1016/j.bbrc.2020.05.087
发表时间：
2020-07-12
影响因子：
3.1
作者：
Choi, Dabin;Kim, Cho-Long;Jeong, Han-Sol
通讯作者：
Jeong, Han-Sol
影响因子：
9
作者：
Choi SW;Lee Y;Shin K;Koo H;Kim D;Sa JK;Cho HJ;Shin HM;Lee SJ;Kim H;Chung S;Shin J;Lee C;Nam DH
通讯作者：
Nam DH