Lipopolysaccharide-induced experimental immune activation does not impair memory functions in humans
Lipopolysaccharide-induced experimental immune activation does not impair memory functions in humans
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DOI：
10.1016/j.nlm.2010.09.011
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发表时间：
2010-11-01
影响因子：
2.7
通讯作者：
Schedlowski, Manfred
中科院分区：
文献类型：
--
作者：
Grigoleit, Jan-Sebastian;Oberbeck, J. Reiner;Schedlowski, Manfred
全身性免疫激活与外周细胞因子的释放一起发生，可以影响中枢神经系统 (CNS) 的行为和功能。然而，暂时性免疫激活过程中记忆和注意力等认知功能是否以及在何种程度上受到影响仍不清楚。我们采用人类内毒素血症模型和标准化神经心理学测试来评估静脉注射前后两组实验性炎症对认知的影响，每组 12 名健康年轻男性 脂多糖（LPS 大肠杆菌 04 ng/kg）或生理盐水 内毒素给药引起严重的短暂生理反应，导致体温升高、循环中性粒细胞数量增加、血浆细胞因子水平 [白细胞介素 (IL)-6 IL-10 肿瘤坏死因子 (TNF)-α] 和去甲肾上腺素浓度增加 ACTH 和皮质醇 然而，免疫和神经内分泌参数的这些变化与记忆表现选择性注意力或执行功能的改变无关 (C) 2010 Elsevier Inc 保留所有权利
Systemic immune activation occuring together with release of peripheral cytokines can affect behavior and the functioning of the central nervous system (CNS) However it remains unknown whether and to what extent cognitive functions like memory and attention are affected during transient immune activation We employed a human endotoxemia model and standardized neuropsychological tests to assess the cognitive effects of an experimental inflammation in two groups of 12 healthy young men before and after intravenous injection of lipopolysaccharide (LPS Escherichia colt 04 ng/kg) or physiological saline Endotoxin administration caused a profound transient physiological response with elevations in body temperature number of circulating neutrophils and increases in plasma cytokine levels [interleukin (IL)-6 IL-10 tumor necrosis factor (TNF)-alpha] and concentrations of norepinephrine ACTH and cortisol However these changes in immune and neuroendocrine parameters were not associated with alterations of memory performance selective attention or executive functions (C) 2010 Elsevier Inc All rights reserved