Particulate matter, oxidative stress and neurotoxicity
Particulate matter, oxidative stress and neurotoxicity
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DOI：
10.1016/j.neuro.2007.12.004
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发表时间：
2008-05-01
期刊：
影响因子：
3.4
通讯作者：
Veronesi, Bellina
中科院分区：
文献类型：
--
作者：
MohanKumar, Sheba M. J.;Campbell, Arezoo;Veronesi, Bellina
颗粒物（PM）是空气污染的一个组成部分，在流行病学上与猝死、心血管和呼吸系统疾病有关。在患有哮喘、糖尿病或阻塞性肺病等疾病的患者中，效果更为明显。临床和实验研究历来集中在PM的心肺效应上。然而，由于PM颗粒携带大量的生物污染物，能够触发自由基的产生和细胞因子的释放，PM可能会影响器官系统敏感的氧化应激的可能性必须加以考虑。这里描述了四项独立的研究，总结了暴露于PM的动物大脑中发现的神经化学和神经病理学变化。这些研究最近在毒理学学会（夏洛特，北卡罗来纳州）和国际神经毒理学协会（蒙特雷，加利福尼亚州）主办的2007年研讨会上发表。(C)2008年爱思唯尔公司All rights reserved.
Particulate matter (PM), a component of air pollution has been epidemiologically associated with sudden deaths, cardiovascular and respiratory illnesses. The effects are more pronounced in patients with pre-existing conditions such as asthma, diabetes or obstructive pulmonary disorders. Clinical and experimental studies have historically focused on the cardiopulmonary effects of PM. However, since PM particles carry numerous biocontaminants that are capable of triggering free radical production and cytokine release, the possibility that PM may affect organs systems sensitive to oxidative stress must be considered. Four independent studies that summarize the neurochemical and neuropathological changes found in the brains of PM exposed animals are described here. These were recently presented at two 2007 symposia sponsored by the Society of Toxicology (Charlotte, NC) and the International Neurotoxicology Association (Monterey, CA). (C) 2008 Elsevier Inc. All rights reserved.