Mechanisms of epigenetic inheritance
Mechanisms of epigenetic inheritance
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DOI：
10.1016/j.ceb.2007.04.002
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发表时间：
2007-06-01
影响因子：
7.5
通讯作者：
Zhang, Yi
中科院分区：
文献类型：
--
作者：
Martin, Cyrus;Zhang, Yi
在细胞分裂期间遗传稳定基因表达模式的机制尚不清楚。染色质受到许多共价修饰，并且通常认为这些修饰在细胞世代之间的转移在遗传中起关键作用，尽管这如何发生是一个争论的问题。在一个提出的模型中，染色质以半保守的方式复制将允许“模板阅读”和“写入”机制将旧组蛋白的修饰复制到新组蛋白。相反，如果染色质以保守的方式复制，那么其他机制，如转录过程中历史的替换和/或修饰，可能介导这些修饰的复制。最后，最近的几项研究表明，DNA甲基化模式的忠实复制可用于传播与基因沉默相关的组蛋白修饰。
The mechanisms by which stable gene expression patterns are inherited during cell division are not well understood. Chromatin is subject to a number of covalent modifications and it is generally believed that the transfer of these modifications between cell generations plays a critical role in inheritance, though how this occurs is a matter of debate. In one proposed model, replication of chromatin in a semi-conservative fashion would allow 'template reading' and 'writing' mechanisms to copy modifications from old histones to new histones. Conversely, if chromatin is replicated in a conservative fashion, then other mechanisms, such as the replacement and/or modification of histories during transcription, may mediate the replication of these modifications. Finally, several recent studies suggest that the faithful replication of DNA methylation patterns may be used to propagate histone modifications associated with gene silencing.