Diatrizoate levels in cerebrospinal fluid following intravenous administration. Role of fluid production rate.
Diatrizoate levels in cerebrospinal fluid following intravenous administration. Role of fluid production rate.
复制标题
静脉注射后脑脊液中泛影酸盐的水平。
DOI：
10.1097/00004424-198805000-00009
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发表时间：
1988
影响因子：
6.7
通讯作者：
Samuel,KA
中科院分区：
文献类型：
--
作者：
Harnish,PP;Northington,FK;Samuel,KA
中枢神经系统（CNS）可能对常规造影剂（CM）的毒性作用高度敏感。目前的研究定量静脉给药后犬脑脊液（CSF）中泛影葡胺的水平，并检查这些水平如何随着CSF产生率降低而变化。在给予泛影葡胺（1 mL/kg推注，随后以12.5 [mu] l/kg/min维持输注，IV）之前和之后，从麻醉犬的小脑延髓池连续采集脑脊液。通过注射乙酰唑胺（30 me/kg，IV）检查CSF产生速率对CSF泛影葡胺水平的影响。通过高效液相色谱法（HPLC）定量CSF中的泛影葡胺水平。基线CSF产生为81.5 [mu] l/min，在泛影葡胺后降至37.4 [mu] l/min，在乙酰唑胺后降至29.5 [mu] l/min。CSF中的地曲唑酯浓度平均为166 [mu] g/mL，乙酰唑胺给药后显著增加至379 [mu] g/mL，血清浓度无变化（1.3 mg/mL）。这些实验结果表明，静脉注射的泛影葡胺可进入中枢神经系统，并且随着脑脊液生成量的减少，这些量可显著增加。这可能有助于解释CM静脉给药后CSF增强和某些CNS毒性。
The central nervous system (CNS) may be highly susceptible to the toxic effects of conventional contrast media (CM). The current study quantifies levels of diatrizoate in canine cerebrospinal fluid (CSF) following intravenous administration and examines how these levels change as CSF production rate is reduced. Cerebro-spinal fluid was collected continuously from the cisterna magna of anesthetized dogs before and after the administration of diatrizoate (1 mL/kg bolus followed by a 12.5 [mu] l/kg/minute maintenance infusion, IV). The influence of CSF production rate on CSF diatrizoate levels was examined by injecting acetazolamide (30 me/kg, IV). Diatrizoate levels in CSF were quantified by a high performance liquid chromatography (HPLC) method. Baseline CSF production was 81.5 [mu] l/minute and dropped to 37.4 [mu] l/minute following diatizoate and to 29.5 [mu] l/minute following acetazolamide. The concentration of distrizoate in CSF averaged 166 [mu] g/mL and increased significantly to 379 [mu] g/mL following acetazolamide with no change in serum coincentration (1.3 mg/mL). These experimental results suggests that appreciable quantities of intravenously administrated diatrizoate may enter the CNS, and that these quantities may increase significantly with reduced CSF productioin. This may help to explain CSF enhancement and certain CNS toxicity after the intravenous administration of CM.