Aberrant expression of pRb, p16, p14ARF, MDM2, p21 and p53 in stage I adenocarcinomas of the lung
Aberrant expression of pRb, p16, p14ARF, MDM2, p21 and p53 in stage I adenocarcinomas of the lung
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I 期肺腺癌中 pRb、p16、p14ARF、MDM2、p21 和 p53 的异常表达
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
T. Nakajima
中科院分区：
文献类型：
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作者：
Q. Xue;T. Sano;K. Kashiwabara;M. Saito;T. Oyama;T. Nakajima
癌症总是与细胞周期异常有关。为了阐明肺腺癌中存在的细胞周期异常，我们对 50 例 I 期肺腺癌的 pRb 和 p53 途径的各种细胞周期调节蛋白进行了免疫组织化学研究。关于pRb途径，大多数腺癌均频繁表达p16和pRb蛋白，并且在约四分之一的I期腺癌中观察到pRb途径的异常表达。关于p53途径，免疫组织化学阳性频率为p14ARF为8%，MDM2为64%，p53为20%，p21为24%。在该通路中，p14ARF 阴性/MDM2 阳性/p53 阴性的免疫组织化学特征是 I 期肺腺癌的特征。 MDM2 和 p53 蛋白之间存在负相关关系，并且与 I 期肺腺癌的分化状态相关。我们的结果表明，pRb 和 p53 通路的破坏在肺腺癌的早期阶段经常观察到，并且可能在肺腺癌的生长和分化中发挥重要作用。
Cancers are always associated with cell cycle abnormalities. To clarify the cell cycle abnormalities present in lung adenocarcinomas, various cell cycle regulatory proteins of both the pRb and p53 pathways were studied immunohistochemically in 50 cases of stage I adenocarcinoma of the lung. In regard to the pRb pathway, most adenocarcinomas showed frequent expression of both p16 and pRb proteins, and aberrant expression in the pRb pathway was observed in about one‐quarter of stage I adenocarcinomas. In regard to the p53 pathway, the frequency of immunohistochemical positivity was 8% for p14ARF, 64% for MDM2, 20% for p53 and 24% for p21. In this pathway, the immunohistochemical profile of p14ARF‐negative/MDM2‐positive/p53‐negative is characteristic of stage I adenocarcinoma of the lung. An inverse relationship was found between MDM2 and p53 protein and was associated with the differentiation status of stage I adenocarcinoma of the lung. Our results suggest that the disruption of the pRb and p53 pathways is frequently observed in the early stages of lung adenocarcinoma and might play an important role in the growth and differentiation of adenocarcinoma of the lung.
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