Brain Regional α-[11C]Methyl-L-Tryptophan Trapping in Medication-Free Patients With Obsessive-Compulsive Disorder
Brain Regional α-[11C]Methyl-L-Tryptophan Trapping in Medication-Free Patients With Obsessive-Compulsive Disorder
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DOI：
10.1001/archgenpsychiatry.2011.16
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发表时间：
2011-07-01
影响因子：
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通讯作者：
Benkelfat, Chawki
中科院分区：
文献类型：
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作者：
Berney, Alexandre;Leyton, Marco;Benkelfat, Chawki
内容：强迫症（OCD）中5-羟色胺（5-羟色胺[5-HT]）功能障碍的假设主要源于5-HT再摄取抑制剂的临床疗效。然而，未用药症状状态下的血清素能异常仍有待充分表征。目的：在符合强迫症标准的无治疗成年人中，研究脑区域5-HT合成，以正电子发射断层扫描和α-[C-11]甲基-L-色氨酸捕获常数（K*）为指标。设计：组间比较。设置：加拿大魁北克麦吉尔大学精神病学系和蒙特利尔神经学研究所，以及麦吉尔大学健康中心心理学系。21例无药物强迫症患者（15名男性，平均[SD]年龄为33.2 [9.3]岁，6名女性，平均[SD]年龄为35.8 [7.1]岁）和21名年龄和性别匹配的健康对照组（15名男性，平均[SD]年龄为32.9 [10.1]岁，6名女性，平均[SD]年龄为36.5.5 [8.6]岁）。α-[C-11]甲基-L-色氨酸脑捕获常数K*，用统计参数图（SPM 8）和比例归一化（范围阈值为100体素，峰值阈值为P
Context: The hypothesis of a serotonin (5-hydroxytryptamine [5-HT]) dysfunction in obsessive-compulsive disorder (OCD) stems largely from the clinical efficacy of 5-HT reuptake inhibitors. Serotonergic abnormalities in the unmedicated symptomatic state, however, remain to be fully characterized.Objective: To investigate brain regional 5-HT synthesis, as indexed by positron emission tomography and the alpha-[C-11]methyl-L-tryptophan trapping constant (K*), in treatment-free adults meeting criteria for OCD.Design: Between-group comparison.Setting: Department of Psychiatry and Montreal Neurological Institute, McGill University, and Department of Psychology, McGill University Health Centre, Quebec, Canada.Participants: Twenty-one medication-free patients with OCD (15 men with a mean [SD] age of 33.2 [9.3] years and 6 women with a mean [SD] age of 35.8 [7.1] years) and 21 healthy controls matched for age and sex (15 men with a mean [SD] age of 32.9 [10.1] years and 6 women with a mean [SD] age of 36.5.5 [8.6] years).Main Outcome Measure: The alpha-[C-11]methyl-L-tryptophan brain trapping constant K*, which was analyzed with Statistical Parametric Mapping (SPM8) and with proportional normalization (extent threshold of 100 voxels with a peak threshold of P