Bacterial infection promotes colon tumorigenesis in ApcMin/+ mice
Bacterial infection promotes colon tumorigenesis in ApcMin/+ mice
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DOI：
10.1086/321998
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发表时间：
2001-07-15
影响因子：
6.4
通讯作者：
Schauer, DB
中科院分区：
文献类型：
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作者：
Newman, JV;Kosaka, T;Schauer, DB
在Apc肿瘤抑制基因的1个等位基因中具有生殖系突变的Min小鼠是人类结直肠癌早期阶段的模型。幽门螺杆菌感染是人类胃癌的一个已知危险因素，可导致慢性炎症和胃上皮细胞增殖增加。已知啮齿类柠檬酸杆菌感染会增加上皮细胞增殖，并促进小鼠结肠中的化学引发肿瘤。感染C.与未感染的Min小鼠相比，1月龄的啮齿动物在6月龄时结肠腺瘤的数量增加了4倍。感染Min小鼠的结肠腺瘤大多数位于远端结肠，其中C。会发生啮齿动物引起的增生。这些数据表明，细菌感染促进遗传易感小鼠的结肠肿瘤形成。
The Min mouse, which has a germ line mutation in 1 allele of the Apc tumor suppressor gene, is a model for the early steps in human colorectal cancer. Helicobacter pylori infection, a known risk factor for gastric cancer in humans, causes chronic inflammation and increased epithelial cell proliferation in the stomach. Infection with the bacterium Citrobacter rodentium is known to increase epithelial cell proliferation and to promote chemically initiated tumors in the colon of mice. Min mice infected with C. rodentium at 1 month of age were found to have a 4-fold increase in the number of colonic adenomas at 6 months of age, compared with uninfected Min mice. Most of the colonic adenomas in the infected Min mice were in the distal colon, where C. rodentium-induced hyperplasia occurs. These data demonstrate that bacterial infection promotes colon tumor formation in genetically susceptible mice.