Thrombocytopenia in the antiphospholipid syndrome
Thrombocytopenia in the antiphospholipid syndrome
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DOI：
10.1136/ard.56.3.194
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发表时间：
1997-03-01
影响因子：
27.4
通讯作者：
Hughes, GRV
中科院分区：
文献类型：
--
作者：
Cuadrado, MJ;Mujic, F;Hughes, GRV
目的-确定血小板减少症的患病率在一组患者患有抗磷脂综合征（APS），并调查这些患者是否可能有任何特殊的临床或血清学特征。一组171例APS患者在我们的部门进行了研究的血小板减少症的存在。这些患者的临床和血清学特征进行了分析，通过标准的方法，他们每个人都与血小板减少症的存在，并与那些发现在组中没有血小板减少症。结果-每个研究的患者有最低限度的三个血小板计数在随访期间。发现40例（23.4%）患者有血小板减少症; 13例患者血小板计数持续偏低，27例患者血小板计数间歇性偏低。与无血小板减少的APS患者组相比，在性别、年龄、病程或诊断方面无统计学显著差异。血小板减少症与血栓形成有关的18例，流产5例，13例同时具有这两种特征。这是4例患者中APS的唯一表现。所有患者抗磷脂抗体检测持续阳性，同时伴有血小板计数降低。血小板减少症和APS patients.Conclusion的临床或血清学表现的存在之间没有显着的关联-这项研究表明，在APS血小板减少症的患病率为23.4%。这些患者没有表现出任何显著的临床或血清学特征，可将其与无血小板减少症的患者区分开来。
Objective - To determine the prevalence of thrombocytopenia in a group of patients suffering from the antiphospholipid syndrome (APS) and to investigate whether these patients may have any particular clinical or serological features.Methods - Retrospective analysis. A group of 171 APS patients seen in our department were studied for the presence of thrombocytopenia. Clinical and serological features of these patients were analysed by standard methods and each of them was correlated to the presence of thrombocytopenia and compared with those found in the group without thrombocytopenia.Results - Each of the patients studied had a minimum of three platelet counts during the follow up period. Forty (23.4%) were found to have thrombocytopenia; 13 with persistently low and 27 patients with intermittently low platelet counts. There were no statistically significant differences in sex, age, disease duration or diagnosis when compared with the group of APS patients without thrombocytopenia. Thrombocytopenia was associated with thrombosis in 18, with miscarriages in five, and with both of these features in 13 patients. It was the only manifestation of the APS in four patients. All patients had persistently positive tests for antiphospholipid antibodies concomitantly with the low platelet counts. No significant association was found between the presence of thrombocytopenia and clinical or serological manifestations in APS patients.Conclusion - This study showed a prevalence of thrombocytopenia of 23.4% in APS. These patients did not present any significant clinical or serological features that distinguish them from those patients without thrombocytopenia.