Luminal peroxides in intestinal thiol-disulfide balance and cell turnover
Luminal peroxides in intestinal thiol-disulfide balance and cell turnover
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DOI：
10.1016/s0305-0491(97)00220-4
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发表时间：
1997-11-01
影响因子：
2.2
通讯作者：
Aw, TY
中科院分区：
文献类型：
--
作者：
Aw, TY
膳食摄入的高度多不饱和脂肪是肠腔中脂质过氧化氢的主要来源。在高过氧化物摄入条件下，过量浓度的脂质氢过氧化物可在肠腔中持续存在，并导致粘膜GSH依赖性解毒途径受损、不依赖于细胞损伤的肠上皮细胞功能障碍以及肠道病理学（包括癌症）的发展。本文总结了我们目前的知识，肠道脂质过氧化氢代谢的决定因素和脂质过氧化氢介导的肠道氧化还原状态的变化，调节粘膜硫醇和抗氧化剂的平衡和控制肠细胞营业额的生理和生化过程。该讨论与了解肠道生理学和病理生理学中的膳食过氧化物和硫醇氧化还原平衡以及口服GSH在保持肠道上皮代谢完整性方面的潜在益处有关。(C)1997年爱思唯尔科学公司
Dietary intake of highly polyunsaturated fats represents a major source of lipid hydroperoxides in the intestinal lumen. Under conditions of high peroxide intake, excessive concentrations of lipid hydroperoxides can persist in the gut lumen and contribute to impairment of mucosal GSH-dependent detoxication pathways, enterocyte dysfunction independent of cell injury, and development of gut pathologies, including cancer. This paper summarizes our current knowledge of the determinants of intestinal lipid hydroperoxide metabolism and of the physiological and biochemical processes in lipid peroxide-mediated changes in intestinal redox status, regulation of mucosal thiol and antioxidant balance and control of intestinal cell turnover. This discussion is pertinent to understanding dietary peroxides and thiol redox balance in intestinal physiology and pathophysiology and the potential benefit of oral GSH in preserving metabolic integrity of the intestinal epithelium. (C) 1997 Elsevier Science Inc.