Platelet factor 4 release from the platelets stored in platelet concentrates
Platelet factor 4 release from the platelets stored in platelet concentrates
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血小板浓缩液中储存的血小板释放血小板因子 4
DOI：
10.1046/j.1537-2995.1985.25586020114.x
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发表时间：
1985
期刊：
影响因子：
2.9
通讯作者：
K. Kato
中科院分区：
文献类型：
--
作者：
T. Shimizu;Y. Ishikawa;Y. Morishima;T. Fukuda;K. Kato
许多人认为在血小板浓缩物（PCs）的储存过程中，血小板的颗粒成分应保持完整，以便在输注时参与止血。本研究旨在确定影响α -颗粒成分血小板因子4 （PF - 4）从储存为pc的血小板中释放的因素。颗粒状血小板按钮的沉降和更强的平床搅拌诱导了显著的PF - 4释放。在22℃下储存1天后，PF‐4的释放百分比与pc的pH值下降大致相关（r = 0.520, y = 0.014 + 7.204）。pH值下降的速率大致与血小板计数成正比。此外，PF‐4释放量与单位体积血小板计数呈正相关（r = 0.615, y = 0.045 + 1.327）。结果表明，决定贮存过程中PF - 4释放量的关键因素之一是浓度ph。降低PCs单位体积血小板计数有利于维持贮存过程中血小板代谢的完整，有利于血小板颗粒成分的维持。
Many consider that granular components of platelets should remain intact during storage of platelet concentrates (PCs) in order to participate in hemostasis when infused. The present investigations were done to determine factors affecting the release of an alpha‐granular component, platelet factor 4 (PF‐4), from platelets stored as PCs. Sedimentation of the pelleted platelet button and stronger flat‐bed agitation induced a significant PF‐4 release. After 1 day of storage at 22 degrees C, the percent PF‐4 release correlated roughly with a pH fall in PCs (r = 0.520, y = 0.014 + 7.204). Rates of pH fall were roughly proportional to the platelet count. In addition, there was a positive relationship between PF‐4 release and the platelet count per unit volume (r = 0.615, y = 0.045 + 1.327). The results indicated that one of the critical factors which determines the amount of PF‐4 release during storage is concentrated pH. Lowering the platelet count per unit volume in PCs is better for the maintenance of granular components in platelets during storage because of the intact platelet metabolism.