Antifungal resistance mechanisms of Aspergillus.
Antifungal resistance mechanisms of Aspergillus.
复制标题
DOI：
10.3314/jjmm.49.157
复制
发表时间：
2008-07
期刊：
影响因子：
--
通讯作者：
Jian Qiao;Wei Liu;Ruoyu Li
中科院分区：
文献类型：
--
作者：
Jian Qiao;Wei Liu;Ruoyu Li
侵袭性曲霉病（IA）是由烟曲霉菌引起的常见病，近年来在免疫功能低下患者中的发病率有所增加，并已成为这些患者的常见死亡原因。抗真菌药耐药性是治疗失败的原因之一。自从第一个对伊曲康唑耐药的A. 1997年报道了10株耐三唑类烟曲霉的临床分离株，烟曲霉的研究也在增加，以及对抗性机制的研究。本文综述了曲霉菌尤其是曲霉菌抗真菌耐药的已知分子机制。fumigatus，审查。
The incidence of invasive aspergillosis (IA) , which is commonly caused by Aspergillus fumigatus, has increased recently in immunocompromised patients and has become the common cause of death in these patients. Antifungal resistance is one of the reasons for treatment failure. Since the first itraconazole-resistant A. fumigatus was reported in 1997, the reports on clinical strains of triazole-resistant A. fumigatus have increased, as well as studies on the resistant mechanisms. In this paper, the known molecular mechanisms of antifungal resistance in Aspergillus, especially in A. fumigatus, are reviewed.