CD5 expression in thymic carcinoma.
CD5 expression in thymic carcinoma.
复制标题
胸腺癌中 CD5 的表达。
作者：
T. Hishima;M. Fukayama;M. Fujisawa;Y. Hayashi;K. Arai;N. Funata;M. Koike
为了确定胸腺癌和胸腺瘤细胞特征之间的差异，采用淋巴细胞标记物进行免疫组化分析（CD 1a、3、4、5、8、10、20、21、25、30、57和72）对23例胸腺上皮肿瘤（淋巴细胞性胸腺瘤除外）进行了检测：显性胸腺癌（OC，n = 7）、非典型胸腺瘤（n = 5）和典型胸腺瘤（上皮性或混合性胸腺瘤，n = 11）。在检查的表面抗原中，CD 5是一种在T细胞中发出细胞生长信号的受体分子，在胸腺的肿瘤上皮细胞、OC（7/7）和非典型胸腺瘤（2/5）中表达，但在典型胸腺瘤中不表达。免疫荧光双标记显示细胞角蛋白阳性细胞表达CD 5。从OC肿瘤中提取的CD 5分子显示与脾脏中的分子大小相同，但在OC和非典型胸腺瘤的上皮细胞中未发现CD 72，CD 72是B细胞表面的CD 5的配体。在其他器官的癌中未观察到CD 5的表达，如肺癌（n = 15）、乳腺癌（n = 4）、食管癌（n = 6）、胃癌（n = 6）、结肠癌（n = 9）和宫颈癌（n = 3）。CD 5与胸腺上皮肿瘤的形态学改变密切相关，并可能通过受体-配体相互作用在OC的演变中发挥作用。
To determine the differences between the cellular characteristics of thymic carcinoma and thymoma, immunohistochemical analysis with lymphocyte markers (CD1a, 3, 4, 5, 8, 10, 20, 21, 25, 30, 57, and 72) was performed on 23 thymic epithelial tumors other than lymphocytic thymoma: overt thymic carcinoma (OC, n = 7), atypical thymoma (n = 5), and typical thymoma (epithelial or mixed thymoma, n = 11). Among the surface antigens examined, CD5, a type of receptor molecule that signals cell growth in T cells, was expressed in neoplastic epithelial cells of the thymus, in OC (seven of seven) and atypical thymoma (two of five), but not in typical thymoma. Double labeling immunofluorescence demonstrated expression of CD5 in cytokeratin-positive cells. The CD5 molecule extracted from an OC tumor showed the same molecular size as that in the spleen, but CD72, a ligand of CD5 on the surface of B cells, was not found in the epithelial cells of OC or atypical thymoma. Expression of CD5 was not observed in carcinomas of other organs, such as lung (n = 15), breast (n = 4), esophagus (n = 6), stomach (n = 6), colon (n = 9), and uterine cervix (n = 3). CD5 is closely related to morphological changes in thymic epithelial tumors and may play a role in the evolution of OC through receptor-ligand interaction.