THE SYNTHESIS AND MICROBIOLOGICAL ACTIVITY OF NEW 4-CHLOROPYRIDIN-2-YL DERIVATIVES
THE SYNTHESIS AND MICROBIOLOGICAL ACTIVITY OF NEW 4-CHLOROPYRIDIN-2-YL DERIVATIVES
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DOI：
10.3987/com-09-11696
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发表时间：
2009-09-01
期刊：
影响因子：
0.6
通讯作者：
Augustynowicz-Kopec, Ewa
中科院分区：
文献类型：
--
作者：
Bogdanowicz, Agnieszka;Foks, Henryk;Augustynowicz-Kopec, Ewa
4-描述了氯吡啶酰胺。所需化合物通过甲基4-氯吡啶并酰肼或4-氯-N '-甲基吡啶并酰肼与合适的抗衡配体（二硫化碳、烷基卤化物、醛、酮、碳酰肼酰胺或异硫氰酸酯）反应或经由4-氯吡啶并酰亚胺酯（通过方便的方法从腈与催化量的DBU获得）形成。筛选所选产品的抑菌和抗结核活性。从4-氯吡啶甲酰胺腙开始合成4-氯吡啶甲酰胺腙衍生物
4-chloropicolinamide is described. The desired compounds were formed by reactions of methyl 4-chloropicolinohydrazonamide or 4-chloro-N'-methylpicolinohydrazonamide with suitable counter partners (carbon disulfide, alkyl halides, aldehydes, ketones, carbohydrazonamides or isothiocyanates) or via 4-chloropicolinimidate, obtained by a convenient method from nitrile with catalytic amount of DBU. Selected products were screened for bacteriostatic and tuberculostatic activity. Synthesis of 4-chloropicolinamidrazone derivatives starting from