Effect of irradiation distance on image contrast in epi-optoacoustic imaging of human volunteers
Effect of irradiation distance on image contrast in epi-optoacoustic imaging of human volunteers
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DOI：
10.1364/boe.5.003765
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发表时间：
2014-11-01
影响因子：
3.4
通讯作者：
Jaeger, Michael
中科院分区：
文献类型：
--
作者：
Held, Gerrit;Preisser, Stefan;Jaeger, Michael
在结合临床光声（OA）和超声（US）成像中，epi-mode辐射和检测集成到一个单一的探头中，提供了灵活的人体成像。然而，落射照明中的成像深度强烈地受杂波的影响。如在以前的幻影实验中所示，照射的位置在杂波产生中起着重要的作用。我们调查的局部图像对比度的临床图像上的照射几何形状的影响，通过改变之间的间隔距离的照射区域和线性超声换能器的声学成像平面在自动扫描设置。不同志愿者的结果表明，当照射区域与探头稍微分离时，图像对比度平均可增强25%，局部可增强两倍以上。我们的研究结果对未来临床应用的光声探针的设计具有重要影响。(C)2014年美国光学学会
In combined clinical optoacoustic (OA) and ultrasound (US) imaging, epi-mode irradiation and detection integrated into one single probe offers flexible imaging of the human body. The imaging depth in epi-illumination is, however, strongly affected by clutter. As shown in previous phantom experiments, the location of irradiation plays an important role in clutter generation. We investigated the influence of the irradiation geometry on the local image contrast of clinical images, by varying the separation distance between the irradiated area and the acoustic imaging plane of a linear ultrasound transducer in an automated scanning setup. The results for different volunteers show that the image contrast can be enhanced on average by 25% and locally by more than a factor of two, when the irradiated area is slightly separated from the probe. Our findings have an important impact on the design of future optoacoustic probes for clinical application. (C) 2014 Optical Society of America