Verbal fl uency in normal aging and cognitive decline: Results of a longitudinal study
Verbal fl uency in normal aging and cognitive decline: Results of a longitudinal study
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DOI：
10.1016/j.csl.2021.101195
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发表时间：
2021-01-17
影响因子：
4.3
通讯作者：
Schroeder, Johannes
中科院分区：
文献类型：
--
作者：
Frankenberg, Claudia;Weiner, Jochen;Schroeder, Johannes
语言流畅性--即在规定的时间间隔内尽可能多地说出给定类别的单词的能力--是诊断痴呆症的神经心理学测试组合的一个组成部分。言语流畅性可以很容易地管理，因此也可以实施在计算机化的痴呆症筛查tests.In本研究中，我们试图调查的能力，音素的言语流畅性作为一个潜在的预测认知能力下降，其协会与声学和词汇功能直接推断口语录音。包括1930年至1932年出生的246名ILSE参与者的数据。受试者在超过10年的时间内由两名委员会认证的老年精神病学家进行了三次调查（t1-t3）：样本的平均年龄在t1为62.77岁，t2为66.36岁，t3为74.22岁。为了评估音素流畅性表现对认知障碍的敏感性，将在t1和t2时获得的分数与认知完整的受试者和在t3时被诊断为轻度认知障碍（MCI）或阿尔茨海默氏痴呆（AD）的受试者之间的重复测量ANOVA进行比较。此外，声学和词汇特征的口语提取与自动语音识别从半结构化的自传体访谈记录在基线。分数与t1时的语言流畅性表现相关。在所有分析中，教育被视为协变量。关于t1和t2时获得的言语流畅性，重复测量方差分析显示，t3时认知完整（HC）的受试者之间的得分显着高于t3时诊断为MCI或AD的受试者。在基线时，言语流畅性与自发言语的重要声学特征显著相关：词率、音素率、言语持续时间和沉默与词的比率。语言流畅性缺陷已经在年轻的老年人中得到证实，并且在从普通人群中招募的一大群人中，几年前就出现了明显的认知下降。口语流利性与口语的声学特征而不是词汇特征有关，这些特征可以直接从自发言语中推断出来。(c)2021爱思唯尔有限公司保留所有权利。
Verbal fluency -i.e. the ability to name as many words of a given category as possible in a defined time interval -is an integral part of neuropsychological test batteries for the diagnosis of dementia. Verbal fluency can be easily administered and thus may also be implemented in computerized dementia screening tests.In the present study we sought to investigate the capability of phonemic verbal fluency as a potential predictor of cognitive decline and its associations with acoustic and lexical features directly inferred from recordings of spoken language. Data from 246 ILSE participants born in the years 1930 to 1932 were included. Subjects were investigated three times (t1-t3) over a period of more than 10 years by two board certified geriatric psychiatrists: the mean age of the sample was 62.77 at t1, 66.36 at t2, and 74.22 at t3. To evaluate the sensitivity of phonemic fluency performance on cognitive impairment, scores obtained at t1 and t2 were compared with repeated measures ANOVA between subjects who were cognitively intact and those who were diagnosed with mild cognitive impairment (MCI) or Alzheimer's dementia (AD) at t3. In addition, acoustic and lexical features of spoken language were extracted with automatic speech recognition from semi-structured autobiographical interviews recorded at baseline. Scores were correlated with verbal fluency performance at t1. In all analyzes education was considered as a covariate. Regarding verbal fluency obtained at t1 and t2, repeated measures ANOVA revealed significantly higher scores between subjects who were cognitively intact (HC) at t3 compared with those diagnosed with MCI or AD at t3. At baseline verbal fluency was significantly correlated with important acoustic features of spontaneous speech: word rate, phoneme rate, speech-duration and silence-to-word-ratio. Verbal fluency deficits were proven already in young old age and precede marked cognitive decline years before in a large group recruited from the general population. Verbal fluency is associated with acoustic rather than lexical features of spoken language which can directly be inferred from spontaneous speech.(c) 2021 Elsevier Ltd. All rights reserved.