Mitotic membrane helps to focus and stabilize the mitotic spindle.
Mitotic membrane helps to focus and stabilize the mitotic spindle.
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有丝分裂膜有助于聚焦和稳定有丝分裂纺锤体。
DOI：
10.1016/j.bpj.2010.09.053
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发表时间：
2010
影响因子：
3.4
通讯作者：
Iglesias,PabloA
中科院分区：
文献类型：
--
作者：
Poirier,ChristopherC;Zheng,Yixian;Iglesias,PabloA
在有丝分裂期间，微管 (MT) 在马达和相关蛋白质的帮助下组装成有丝分裂纺锤体。最近的证据支持膜纺锤体基质有助于纺锤体形成的观点。然而，基质有助于主轴组装的机制尚不清楚。为了寻找有丝分裂膜的存在可能有助于纺锤体形态的机制，我们建立了一个计算模型来探索这些成分之间的相互作用。我们表明，有丝分裂器周围的弹性膜有助于聚焦 MT 负端，并提供对抗正端定向 MT 马达（如 Eg5）的阻力。
During mitosis, microtubules (MTs), aided by motors and associated proteins, assemble into a mitotic spindle. Recent evidence supports the notion that a membranous spindle matrix aids spindle formation; however, the mechanisms by which the matrix may contribute to spindle assembly are unknown. To search for a mechanism by which the presence of a mitotic membrane might help spindle morphology, we built a computational model that explores the interactions between these components. We show that an elastic membrane around the mitotic apparatus helps to focus MT minus ends and provides a resistive force that acts antagonistically to plus-end-directed MT motors such as Eg5.