Nitric Oxide and Lutein: Function, Performance, and Protection of Neural Tissue.
Nitric Oxide and Lutein: Function, Performance, and Protection of Neural Tissue.
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DOI：
10.3390/foods4040678
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发表时间：
2015-11-11
期刊：
影响因子：
--
通讯作者：
Stringham NT
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文献类型：
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作者：
Stringham JM;Stringham NT
可溶性气体神经递质一氧化氮(NO)在视网膜和大脑中具有许多重要的代谢和神经调节功能。尽管一氧化氮对正常的神经功能是必需的，但它在神经毒性中发挥着重要作用。这通常见于涉及神经组织氧化应激和炎症的疾病状态，如老年性黄斑变性和阿尔茨海默病。膳食中的叶黄素类胡萝卜素(L)是一种强大的抗氧化剂和抗炎剂，如果摄入足够多，就会沉积在需要大量代谢需求的神经组织中。其中一些特定的组织，如中央视网膜和大脑额叶，受到与年龄有关的疾病的影响，如上述疾病。代谢需求、NO和L之间的明显对应关系暗示着一种动态平衡关系，这种关系有助于促进正常功能、提高性能和保护脆弱的神经组织。本文的目的就是对这些方面的文献进行综述。
The soluble gas neurotransmitter nitric oxide (NO) serves many important metabolic and neuroregulatory functions in the retina and brain. Although it is necessary for normal neural function, NO can play a significant role in neurotoxicity. This is often seen in disease states that involve oxidative stress and inflammation of neural tissues, such as age-related macular degeneration and Alzheimer’s disease. The dietary xanthophyll carotenoid lutein (L) is a potent antioxidant and anti-inflammatory agent that, if consumed in sufficient amounts, is deposited in neural tissues that require substantial metabolic demand. Some of these specific tissues, such as the central retina and frontal lobes of the brain, are impacted by age-related diseases such as those noted above. The conspicuous correspondence between metabolic demand, NO, and L is suggestive of a homeostatic relationship that serves to facilitate normal function, enhance performance, and protect vulnerable neural tissues. The purpose of this paper is to review the literature on these points.