Chorea in patients with AIDS
Chorea in patients with AIDS
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艾滋病患者舞蹈病
DOI：
10.1111/j.1600-0404.1999.tb00406.x
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发表时间：
1999
影响因子：
3.5
通讯作者：
F. Girotti
中科院分区：
文献类型：
--
作者：
L. Piccolo;R. Causarano;R. Sterzi;M. Sberna;P. Oreste;C. Moioli;L. Caggese;F. Girotti
目的-描述一系列艾滋病患者舞蹈动作的不同病因和可能的解剖临床相关性。方法-对1994年1月至1996年12月在我中心连续出现舞蹈病的5例艾滋病患者的临床资料和神经影像学资料进行分析。结果-局灶性舞蹈运动障碍2例，右半侧舞蹈症1例，全身性舞蹈症2例。急性发热1例，亚急性4例。1例舞蹈病为艾滋病发病症状；1例为亚急性。另一项舞蹈动作是艾滋病诊断后的第一个神经系统症状； 2 名 AIDS 患者除舞蹈病外还出现神经系统症状；第五名患者在出现细菌性脑炎后出现颊面运动障碍。结论- 2 名患者的舞蹈病与脑弓形虫病相关，1 名患者的进行性多灶性白质脑病，另一名患者的亚急性 HIV 脑病，最后一名患者可能是医源性的。舞蹈病在艾滋病中并不罕见，但其病因多种多样，需要仔细的神经放射学和临床评估才能识别它们。对于没有运动障碍家族史的年轻舞蹈病患者，应考虑艾滋病相关疾病。
Objective‐ To describe differing etiologies and possible anatomo‐clinical correlates of choreic movements in a series of AIDS patients. Methods‐ We analyzed the clinical records and neuroimaging data of 5 consecutive AIDS patients who developed choreic movements at our center from January, 1994 to December, 1996. Results‐ There were 2 cases of focal choreic dyskinesias, 1 of right hemichorea, and 2 of generalized chorea. Onset was acute and febrile in 1 case, and subacute in the other 4. In 1 patient the chorea was the AIDS onset symptom; in another choreic movements were the first neurological symptom following AIDS diagnosis; in 2 patients AIDS had a neurological onset other than chorea; and in the fifth patient buccofacial dyskinesias appeared following the development of bacterial encephalitis. Conclusion‐ Chorea was associated with cerebral toxoplasmosis in 2 patients, progressive multifocal leukoencephalopathy in 1, subacute HIV encephalopathy in another, and was probably iatrogenic in the last. Chorea is not unusual in AIDS, however the causes are variable and careful neuroradiological and clinical evaluation is required to identify them. AIDS‐related disease should be considered in young patients presenting with chorea without a family history of movement disorders.