Massive accumulation of 11C-Pittsburg compound B in the occipital lobes of a patient with early-onset dementia accompanied by muscle weakness and hypertonicity
Massive accumulation of 11C-Pittsburg compound B in the occipital lobes of a patient with early-onset dementia accompanied by muscle weakness and hypertonicity
复制标题
11C-匹兹堡化合物 B 在患有早发性痴呆并伴有肌无力和肌张力过高的患者枕叶中大量积聚
DOI：
10.1007/s12149-013-0762-0
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发表时间：
2013
期刊：
影响因子：
2.6
通讯作者：
Matsuda H
中科院分区：
文献类型：
--
作者：
Ito K;Sano T;Kamiya K;Nakata Y;Shigemoto Y;Sato N;Oya Y;Matsuda H
一名44岁女性在出现进行性痴呆、肌肉无力和高张力后，接受了11c -匹兹堡化合物B （11C-PiB）、18f -氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（PET/CT）、99mtc -乙基半胱氨酸二聚体单光子发射计算机断层扫描和磁共振成像。她的一些家庭成员死于肌肉无力和病因不明的早发性痴呆。神经学和心理检查显示一般领域中度痴呆和上肢肌肉无力。11C-PiB PET/CT显示双侧枕叶淀粉样蛋白异常堆积，而正常高摄取区域如白质的11C-PiB生理摄取相对减少。脑脊液淀粉样蛋白-β减少，脑脊液总蛋白和磷酸化tau蛋白升高。该病例可能代表了一种新的淀粉样蛋白沉积疾病，其特征是早发性痴呆、肌肉无力和高渗性，或者至少是变异性AD中PiB的一种新的摄取模式。
A 44-year-old woman underwent 11C-Pittsburg compound B (11C-PiB), 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT), 99mTc-ethyl-cysteinate-dimer single photon emission computed tomography, and magnetic resonance imaging after presenting with progressive dementia, muscle weakness, and hypertonicity. Some of her family members had died of muscle weakness with early-onset dementia of unknown etiology. Neurological and psychological examinations revealed moderate dementia in general fields and muscle weakness in her upper limbs. 11C-PiB PET/CT revealed abnormal accumulations of amyloid in the bilateral occipital lobes, while physiological uptakes of 11C-PiB in areas that normally show high uptake, such as white matter, appeared relatively decreased. Meanwhile, cerebrospinal fluid (CSF) amyloid-β was decreased, and CSF total and phosphorylated tau proteins were increased. This case may be representative of a new category of amyloid deposition disease characterized by early-onset dementia, muscle weakness, and hypertonicity, or at least, a new uptake pattern of PiB in variant AD.