RESPONSE OF MURINE EPIDERMIS TO 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN - INTERACTION OF THE AH AND HR LOCI
RESPONSE OF MURINE EPIDERMIS TO 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN - INTERACTION OF THE AH AND HR LOCI
复制标题
DOI：
10.1016/0092-8674(82)90028-9
复制
发表时间：
1982-01-01
期刊：
影响因子：
64.5
通讯作者：
POLAND, A
中科院分区：
文献类型：
--
作者：
KNUTSON, JC;POLAND, A
2，3，7，8-四氯二苯并-对-二恶英（TCDD）和相关的卤代芳烃在携带隐性突变（hr/hr）无毛小鼠的皮肤中产生表皮增生、角化过度和皮脂腺化生。这种反应是通过介导的胞质受体蛋白：受体结合的结构-活性关系对应于生产的皮肤病变，这些组织病理学变化分离与遗传多态性在Ah基因座，基因座决定的胞质受体。在HRS/J小鼠（一种分离hr基因座的近交系）中，无毛（hr/hr）和有毛（hr/+）小鼠均具有高亲和力细胞质受体，并通过诱导表皮芳烃羟化酶活性（受体介导的生化反应）对TCDD作出反应;然而，只有hr/hr小鼠出现增殖/化生皮肤反应。的遗传模型提出的Ah和hr位点的相互作用，占TCDD的HRS/J，hr/hr和hr/+小鼠的皮肤中观察到的差异反应。
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related halogenated aromatic hydrocarbons produce epidermal hyperplasia, hyperkeratosis and sebaceous gland metaplasia in the skin of mice bearing the recessive mutation (hr/hr) hairless. This response is mediated through the cytosol receptor protein: the structure-activity relationship for receptor binding corresponds to that for production of the skin lesion, and these histopathological changes segregate with the genetic polymorphism at the Ah locus, the locus determining the cytosol receptor. In HRS/J mice, an inbred strain segregating for the hr locus, both hairless (hr/hr) and haired (hr/+) mice possess the high-affinity cytosol receptor and respond to TCDD with the induction of epidermal aryl hydrocarbon hydroxylase activity, a receptor-mediated biochemical response; however, only hr/hr mice develop the proliferative/metaplastic skin response. A genetic model is proposed for the interaction of the Ah and hr loci, to account for the differential response to TCDD observed in the skin of HRS/J, hr/hr and hr/+ mice.