PATHOLOGY AND PATHOGENESIS OF LUMBAR SPONDYLOSIS AND STENOSIS
PATHOLOGY AND PATHOGENESIS OF LUMBAR SPONDYLOSIS AND STENOSIS
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DOI：
10.1097/00007632-197812000-00004
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发表时间：
1978-01-01
期刊：
影响因子：
3
通讯作者：
REILLY J
中科院分区：
文献类型：
--
作者：
KIRKALDY-WILLIS W H;WEDGE J H;REILLY J
对人体腰椎尸检标本的研究使得构建一系列病理变化成为可能。后关节的进行性退行性改变导致明显的破坏和不稳定。椎间盘的类似变化会导致突出、内部破坏和吸收。后关节和椎间盘的联合变化有时会导致侧隐窝中的脊神经卡压、一级中央狭窄或这两种情况同时发生。多年来，一级的变化通常会导致多节段脊椎病和/或狭窄。发育性狭窄是小疝气或中度退行性狭窄存在的增强因素。诸如重大创伤、脊椎滑脱、脊柱融合后的病变、佩吉特氏病和氟中毒等病变有时会直接产生中央或侧部狭窄。
Study of human autopsy specimens of the lumbar spine makes it possible to construct a spectrum of pathologic change. Progressive degenerative changes in the posterior joints lead to marked destruction and instability. Similar changes in the disc result in herniation, internal disruption and resorption. Combined changes in posterior joint and disc sometimes produce entrapment of a spinal nerve in the lateral recess, central stenosis at 1 level, or both of these conditions. Changes at 1 level often lead, over a period of years, to multilevel spondylosis and/or stenosis. Developmental stenosis is an enhancing factor in the presence of a small herniation or moderate degenerative stenosis. Lesions such as major trauma, spondylolisthesis, those following spinal fusion, Paget's disease and fluorosis, on occasion act directly to produce central or lateral stenosis.