NMDA AS WELL AS NON-NMDA RECEPTOR ANTAGONISTS CAN PREVENT THE PHASE-SHIFTING EFFECTS OF LIGHT ON THE CIRCADIAN SYSTEM OF THE GOLDEN-HAMSTER
NMDA AS WELL AS NON-NMDA RECEPTOR ANTAGONISTS CAN PREVENT THE PHASE-SHIFTING EFFECTS OF LIGHT ON THE CIRCADIAN SYSTEM OF THE GOLDEN-HAMSTER
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DOI：
10.1177/074873049200700204
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发表时间：
1992-06-01
影响因子：
3.5
通讯作者：
MENAKER, M
中科院分区：
文献类型：
--
作者：
COLWELL, CS;MENAKER, M
本实验的目的是评估是否脑室注射兴奋性氨基酸（EAA）受体拮抗剂将防止光诱导的相位变化的昼夜节律的车轮运行活动在仓鼠。给予非N-甲基-D-天冬氨酸（非NMDA）拮抗剂6，7-二硝基喹喔啉-2，3-二酮（DNQX）可阻断光诱导的相位提前和延迟。同样，竞争性NMDA受体拮抗剂，3（2-羧基哌嗪-4-基）-丙基-1-膦酸（CPP）的管理，防止光诱导的相位提前和延迟。两种药物本身都没有对节律的相位产生任何一致的影响。这些数据提供了进一步的证据表明，EAA受体介导光对昼夜节律系统的影响，并表明NMDA和非NMDA受体类型可能参与其中。
The present experiments were designed to evaluate whether the intraventricular administration of excitatory amino acid (EAA) receptor antagonists would prevent light-induced phase shifts of the circadian rhythm of wheel-running activity in the hamster. Administration of the non-N-methyl-D-aspartate (non-NMDA) antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX) blocked light-induced phase advances and delays. Similarly, administration of the competitive NMDA receptor antagonist, 3(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), prevented light-induced phase advances and delays. Neither drug by itself caused any consistent effect on the phase of the rhythm. These data provide further evidence that EAA receptors mediate the effects of light on the circadian system, and suggest that both NMDA and non-NMDA receptor types may be involved.