Positron emission tomographic studies of perceptual tasks.
Positron emission tomographic studies of perceptual tasks.
复制标题
感知任务的正电子发射断层扫描研究。
DOI：
10.1002/ana.410150712
复制
发表时间：
1984
影响因子：
11.2
通讯作者：
Gur,RC
中科院分区：
文献类型：
--
作者：
Reivich,M;Alavi,A;Gur,RC
代谢映射结合正电子发射断层扫描被用来检查人脑对生理刺激的反应。通过氟-18-标记的氟脱氧葡萄糖技术测量局部脑葡萄糖消耗。各种灰质结构的测量的变异系数从19.5%到26.4%不等。如果使用碳11标记的脱氧葡萄糖作为示踪剂在同一受试者中进行重复测量，则这些相同结构的重复测量的变异系数降低到5.2%至8.7%之间。刺激正常受试者的一个视野，对侧视皮层的代谢显著增加（p<0.01）。通过耳机向一只耳朵呈现由磁带记录的事实故事组成的听觉刺激，使对侧颞叶皮层的葡萄糖消耗显著增加（p<0.001）。同时还研究了警觉或注意对脑代谢的影响。与没有参与视觉或听觉任务的受试者相比，参与视觉或听觉任务的受试者的右下顶叶区域的代谢明显高于左下顶叶区域。与左脑相比，在测量过程中焦虑水平较高的受试者，焦虑似乎在右脑产生了更大的葡萄糖利用率。代谢图谱有望成为一个强大的新工具，以促进我们对人类大脑的组织和功能的理解。
Metabolic mapping in conjunction with positron emission tomography was used to examine the response of the human brain to physiological stimuli. Local cerebral glucose consumption was measured by means of the fluorine‐18‐labeled fluorodeoxyglucose technique. The coefficient of variation of this measurement for various gray matter structures varies from 19.5 to 26.4%. If repeat measurements are made in the same subject using carbon‐11‐labeled deoxyglucose is the tracer, the coefficient of variation of repeat measurements for these same structures is reduced to between 5.2 and 8.7%. Stimulation of one visual field in normal subjects produced a significant (p<0.01) increase in metabolism in the contralateral visual cortex. An auditory stimulus consisting of a tape‐recorded factual story presented through earphones to only one ear produced a significant (p<0.001) increase in glucose consumption in the contralateral temporal cortex. The effects of vigilance or attention on cerebral metabolism were also examined. There was significantly greater metabolism in the right versus the left inferior parietal region in subjects attending to a visual or auditory task compared with those who were not. Anxiety appeared to produce significantly greater glucose utilization in the right hemisphere compared with the left in those subjects who had a higher level of anxiety during the measurement. Metabolic mapping promises to be a powerful new tool in furthering our understanding of the organization and functioning of the human brain.