NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'.
NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'.
复制标题
DOI：
10.1515/bmc-2013-0023
复制
发表时间：
2013-10
影响因子：
--
通讯作者：
Soares DC
中科院分区：
文献类型：
--
作者：
Bradshaw NJ;Hennah W;Soares DC
核分布元件1（NDE 1，也称为NudE）和NDE样1（NDEL1，也称为Nudel）是有丝分裂和神经发育所必需的旁系同源蛋白，与精神和神经发育障碍有关。这两种蛋白质具有高度的序列相似性，并已被证明可以相互作用。在体内和细胞培养中的大量实验证据表明，这些蛋白质具有共同的功能，尽管最近出现了两者之间不同功能的实例。我们回顾了NDE1和NDEL1在结构解析和细胞功能方面的最新进展，重点是它们不同的翻译后修饰机制。基于文献回顾和生物信息学评估，我们提出的概念，双蛋白NDE1和NDEL1，而共享一个类似的“性质”，在其结构和基本功能方面，似乎是不同的，在他们的“养育”，在其中，他们都在细胞内的表达和翻译后修饰方面的调节方式。这些差异可能对理解NDE1和NDEL1在神经发育和疾病中的特定作用具有重要意义。
Nuclear distribution element 1 (NDE1, also known as NudE) and NDE-like 1 (NDEL1, also known as Nudel) are paralogous proteins essential for mitosis and neurodevelopment that have been implicated in psychiatric and neurodevelopmental disorders. The two proteins possess high sequence similarity and have been shown to physically interact with one another. Numerous lines of experimental evidence in vivo and in cell culture have demonstrated that these proteins share common functions, although instances of differing functions between the two have recently emerged. We review the key aspects of NDE1 and NDEL1 in terms of recent advances in structure elucidation and cellular function, with an emphasis on their differing mechanisms of post-translational modification. Based on a review of the literature and bioinformatics assessment, we advance the concept that the twin proteins NDE1 and NDEL1, while sharing a similar ‘nature’ in terms of their structure and basic functions, appear to be different in their ‘nurture’, the manner in which they are regulated both in terms of expression and of post-translational modification within the cell. These differences are likely to be of significant importance in understanding the specific roles of NDE1 and NDEL1 in neurodevelopment and disease.