gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice.
gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice.
复制标题
GRO-BETA是-c-x-c-趋化因子，是一种血管生成抑制剂，可抑制小鼠刘易斯肺癌的生长。
DOI：
10.1084/jem.182.6.2069
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发表时间：
1995-12-01
期刊：
影响因子：
--
通讯作者：
Folkman J
中科院分区：
文献类型：
--
作者：
Cao Y;Chen C;Weatherbee JA;Tsang M;Folkman J
我们发现两种趋化因子，重组gro-α和gro-β，以剂量依赖性方式特异性抑制生长因子刺激的毛细血管内皮细胞增殖，而gro-γ没有抑制作用。在鸡绒毛尿囊膜试验中，gro-beta在体内抑制血管形成。在小鼠中全身给药后，其足以有效抑制碱性成纤维细胞生长因子诱导的角膜新生血管形成。此外，gro-beta显著抑制小鼠刘易斯肺癌在同基因C57 B16/J和免疫缺陷裸鼠中的生长而没有毒性。在体外，刘易斯肺癌细胞对显著抑制内皮细胞增殖的高浓度重组gro-beta完全不敏感。这一发现支持了gro-beta通过抑制肿瘤诱导的新血管形成来抑制刘易斯肺肿瘤生长的结论。
We have found that two chemokines, recombinant gro-alpha and gro-beta, specifically inhibit growth factor-stimulated proliferation of capillary endothelial cells in a dose-dependent manner, whereas gro- gamma has no inhibitory effect. In vivo, gro-beta inhibits blood vessel formation in the chicken chorioallantoic membrane assay. It is sufficiently potent to effectively suppress basic fibroblast growth factor-induced corneal neovascularization after systemic administration in mice. Further, gro-beta significantly inhibits the growth of murine Lewis lung carcinoma in syngeneic C57B16/J and immunodeficient nude mice without toxicity. In vitro, Lewis lung carcinoma cells are completely insensitive to recombinant gro-beta at high concentrations that significantly inhibit endothelial cell proliferation. This finding supports the conclusion that gro-beta inhibits Lewis lung tumor growth by suppression of tumor-induced neovascularization.