Migration and granulomatous reaction after periurethral injection of polytef (Teflon).
Migration and granulomatous reaction after periurethral injection of polytef (Teflon).
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尿道周围注射聚四氟乙烯（Teflon）后的迁移和肉芽肿反应。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
W. Utz
中科院分区：
文献类型：
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作者：
A. Malizia;H. M. Reiman;Robert P. Myers;J. Sande;S. Barham;R. Benson;M. Dewanjee;W. Utz
虽然尿道周围注射polytef糊剂已成功治疗尿失禁患者，但在大陆动物中进行的这项研究证实了polytef颗粒从注射部位迁移。我们将聚四氟乙烯糊注射到雌性狗和雄性猴子的会阴部。在50至70天时，7只动物中有6只在盆腔淋巴结中发现颗粒，7只动物中有4只在肺中发现颗粒（未研究肾脏和大脑）;在10个半月时，7只动物中有7只在盆腔淋巴结、肺和大脑中发现颗粒; 7只动物中有4只在肾脏中发现颗粒; 7只动物中有2只在脾脏中发现颗粒。X射线显微分析证实这些颗粒是聚四氟乙烯。在10 1/2个月时，在所有注射部位和一些远处迁移部位发现了polytef肉芽肿。由于这些肉芽肿意味着慢性异物反应，我们认为，在已知对人类的长期影响之前，polytef糊剂不应用于儿童或具有正常预期寿命的年轻人。
Although patients with urinary incontinence have been treated successfully by periurethral injection of polytef paste, this study in continent animals demonstrates migration of polytef particles from the injection site. We injected polytef paste periurethrally into female dogs and male monkeys. Particles were found at 50 to 70 days in pelvic nodes in six of seven animals and lungs in four of seven (the kidneys and brain were not studied); and at 10 1/2 months in pelvic nodes, lungs, and brain in seven of seven; kidneys in four of seven; and spleen in two of seven. X-ray microanalysis confirmed that the particles were polytef. At 10 1/2 months, polytef granulomas were found at all injection sites and some sites of distant migration. Since these granulomas signify chronic foreign-body reaction, we believe that until the long-term effects in humans are known, polytef paste should not be used in children or young adults with normal life expectancy.