Comparative fracture risk in vegetarians and nonvegetarians in EPIC-Oxford
Comparative fracture risk in vegetarians and nonvegetarians in EPIC-Oxford
复制标题
DOI：
10.1038/sj.ejcn.1602659
复制
发表时间：
2007-12-01
影响因子：
4.7
通讯作者：
Key, T.
中科院分区：
文献类型：
--
作者：
Appleby, P.;Roddam, A.;Key, T.
目的：比较四个饮食组的骨折率（肉食者、鱼类食用者、素食者和纯素食者）在欧洲癌症和营养前瞻性调查的牛津队列中（EPIC-Oxford）。设计：随访时自我报告骨折风险的前瞻性队列研究。地点：英国。受试者：通过邮寄方式和全科手术招募了7947名男性和26749名女性，年龄在20-89岁之间，其中包括19249名肉食者、4901名鱼类食用者、9420名素食者和1126名素食者。方法：考克斯回归。结果：在平均5.2年的随访中，343名男性和1555名女性报告了一处或多处骨折。与肉食者相比，调整性别、年龄和非饮食因素后，男性和女性的骨折发病率比值分别为：鱼类1.01（95%CI 0.88-1.17），素食者1.00（0.89-1.13），纯素食者1.30（1.02-1.66）。在进一步调整膳食能量和钙摄入量后，素食者与肉食者的发病率比为1.15（0.89-1.49）。在摄入至少525毫克/天钙的受试者中，相应的发病率比为1.05（0.90-1.21）的鱼吃，1.02（0.90-1.15）的素食者和1.00（0.69-1.44）的纯素主义者。结论：在这个人群中，骨折的风险是相似的肉食者，鱼吃和素食者。素食者骨折风险较高似乎是由于他们的平均钙摄入量相当低。充足的钙摄入量对骨骼健康至关重要，无论饮食偏好如何。赞助：EPIC-牛津研究由医学研究理事会和英国癌症研究所支持。
Objective: To compare fracture rates in four diet groups (meat eaters, fish eaters, vegetarians and vegans) in the Oxford cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford).Design: Prospective cohort study of self-reported fracture risk at follow-up.Setting: The United Kingdom.Subjects: A total of 7947 men and 26 749 women aged 20-89 years, including 19 249 meat eaters, 4901 fish eaters, 9420 vegetarians and 1126 vegans, recruited by postal methods and through general practice surgeries.Methods: Cox regression.Results: Over an average of 5.2 years of follow-up, 343 men and 1555 women reported one or more fractures. Compared with meat eaters, fracture incidence rate ratios in men and women combined adjusted for sex, age and non-dietary factors were 1.01 (95% CI 0.88-1.17) for fish eaters, 1.00 (0.89-1.13) for vegetarians and 1.30 (1.02-1.66) for vegans. After further adjustment for dietary energy and calcium intake the incidence rate ratio among vegans compared with meat eaters was 1.15 (0.89-1.49). Among subjects consuming at least 525 mg/day calcium the corresponding incidence rate ratios were 1.05 (0.90-1.21) for fish eaters, 1.02 (0.90-1.15) for vegetarians and 1.00 (0.69-1.44) for vegans.Conclusions: In this population, fracture risk was similar for meat eaters, fish eaters and vegetarians. The higher fracture risk in the vegans appeared to be a consequence of their considerably lower mean calcium intake. An adequate calcium intake is essential for bone health, irrespective of dietary preferences.Sponsorship: The EPIC-Oxford study is supported by The Medical Research Council and Cancer Research UK.