Effect of endogenous pancreatic glucagon on gastric acid secretion in patients with duodenal ulcer before and after parietal cell vagotomy.
Effect of endogenous pancreatic glucagon on gastric acid secretion in patients with duodenal ulcer before and after parietal cell vagotomy.
复制标题
内源性胰高血糖素对十二指肠溃疡壁细胞迷走神经切断术前后胃酸分泌的影响
作者：
F. B. Loud;J. Chirstiansen;J. Holst;B. Petersen;P. Kirkegaard
通过静脉滴注1-精氨酸，观察了十二指肠溃疡患者壁细胞迷走神经切断术（PCV）前后内源性胰高血糖素对次最大五肽胃泌素刺激胃酸分泌的影响。术前输注1-精氨酸导致显着抑制酸分泌，而术后没有发现效果。血浆胰高血糖素浓度在术前和术后、空腹以及精氨酸输注期间相同。PCV后血清胃泌素浓度升高，但不受精氨酸输注的影响，术前和术后。研究表明，胃底腺的完整迷走神经支配是通过输注1-精氨酸释放的胰高血糖素抑制五肽胃泌素诱导的酸分泌的条件。
The effect of endogenous pancreatic glucagon on submaximal pentagastrin stimulated gastric acid secretion was studied by infusion of 1-arginine in patients with duodenal ulcer before and after parietal cell vagotomy without drainage (PCV). Preoperatively infusion of 1-arginine resulted in a marked inhibition of acid secretion, whereas no effect was found postoperatively. Plasma glucagon concentrations were identical pre- and postoperatively, fasting as well as during arginine infusion. Serum gastrin concentration rose after PCV but not unaffected by arginine infusion both pre- and postoperatively. The study demonstrates that intact vagal innervation of the fundic glands is a condition of inhibition of pentagastrin induced acid secretion by pancreatic glucagon released by infusion of 1-arginine.